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Details on Person The function of MDC1 in recruiting and retaining DNA repair ...
| Class:Id | Summation:5693570 |
|---|---|
| _displayName | The function of MDC1 in recruiting and retaining DNA repair ... |
| _timestamp | 2021-08-16 22:07:38 |
| created | [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 |
| literatureReference | [LiteratureReference:83588] NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. [LiteratureReference:83562] MDC1 is a mediator of the mammalian DNA damage checkpoint. [LiteratureReference:83563] MDC1 is required for the intra-S-phase DNA damage checkpoint. |
| modified | [InstanceEdit:5693622] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6784748] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:9750854] Orlic-Milacic, Marija, 2021-08-16 |
| text | The function of MDC1 in recruiting and retaining DNA repair proteins at the sites of DNA damage (Xu and Stern 2003, Stewart et al. 2003) is promoted by the ATM-mediated phosphorylation of MDC1 (Liu et al. 2012). Phosphorylation of MDC1 (NFBD1) by ATM at threonine residue T4 stabilizes otherwise unstable MDC1 homodimers by enabling in trans interaction of MDC1 FHA domains with phosphorylated N-terminal threonine residues (Goldberg et al. 2003, Liu et al. 2012). ATM also phosphorylates MDC1 on at least four threonine residues that match the consensus RNF8-binding sequence T-Q-X-F: T699, T719, T752, T765 (Kolas et al. 2007). Binding of the ubiquitin ligase RNF8 to ATM phosphorylated MDC1 is necessary for the recruitment of TP53BP1 and BRCA1 to DNA double-strand break (DSB) sites. |
| (summation) | [Reaction:5693536] ATM phosphorylates MDC1 [Homo sapiens] |
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