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Details on Person ATM phosphorylates histone H2AFX on S139 at DNA DSBs

Class:Id	Reaction:5693549
_displayName	ATM phosphorylates histone H2AFX on S139 at DNA DSBs
_doRelease	TRUE
_timestamp	2022-09-13 18:04:04
authored	[InstanceEdit:75141] Matthews, L, 2003-08-11 05:43:00
catalystActivity	[CatalystActivity:5682178] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[SimpleEntity:29358] ATP [nucleoplasm] [Complex:5693563] DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:83547] A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. [LiteratureReference:914123] ATM phosphorylates histone H2AX in response to DNA double-strand breaks [LiteratureReference:83590] DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. [LiteratureReference:75188] Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. [LiteratureReference:5682460] Genomic instability in mice lacking histone H2AX [LiteratureReference:5683957] Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
modified	[InstanceEdit:5693622] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6784748] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:6784750] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9816782] Orlic-Milacic, Marija, 2022-09-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ATM phosphorylates histone H2AFX on S139 at DNA DSBs
output	[SimpleEntity:113582] ADP [nucleoplasm] [Complex:5683952] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5693602] ATM recognizes H2AFX-Nucleosomes [Homo sapiens] [Reaction:5683930] WICH phosphorylates H2AFX on Y142 [Homo sapiens] [Reaction:5693598] ATM phosphorylates NBN [Homo sapiens]
releaseDate	2003-11-03
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796808] R-HSA-5693549.3
summation	[Summation:5693610] ATM phosphorylates histone H2AFX (H2AX) on serine S139 withi...
(hasEvent)	[Pathway:5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks [Homo sapiens]
(precedingEvent)	[Reaction:5683964] ATM phosphorylates EYA1-4 [Homo sapiens] [Reaction:5683986] APBB1 and MAPK8 bind diphosphorylated H2AFX [Homo sapiens]
(replacementInstances)	[_Deleted:6793162] Deletion of instance: 75242
(updatedInstance)	[_UpdateTracker:9775919] Update Tracker - [Reaction:5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - v78:[modifyText]
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