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Details on Person MRN activates ATM
Class:Id Reaction:5693540 _displayName MRN activates ATM _doRelease TRUE _timestamp 2015-09-04 20:34:26 authored [InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15 catalystActivity [CatalystActivity:5694649] protein serine/threonine kinase activity of DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] compartment [Compartment:7660] nucleoplasm created [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 edited [InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15 [InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 input [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [Complex:5682035] DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:912403] ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex [LiteratureReference:5682032] DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity [LiteratureReference:5682134] Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair [LiteratureReference:5682124] Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A [LiteratureReference:83540] DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation [LiteratureReference:5682140] Involvement of novel autophosphorylation sites in ATM activation [LiteratureReference:5682155] Nuclear retention of ATM at sites of DNA double strand breaks [LiteratureReference:111549] Requirement of the MRN complex for ATM activation by DNA damage. [LiteratureReference:5682146] Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex modified [InstanceEdit:5693622] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:5693904] Orlic-Milacic, Marija, 2015-05-18 [InstanceEdit:5694650] Orlic-Milacic, Marija, 2015-05-22 [InstanceEdit:6784748] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name MRN activates ATM output [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [Complex:5682055] DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5693527] p-S1981,Ac-K3016-ATM [nucleoplasm] [Homo sapiens] precedingEvent
releaseDate 2013-09-18 reviewed [InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03 [InstanceEdit:5693179] Borowiec, James A, 2015-06-12 reviewStatus [ReviewStatus:9821382] five stars revised [InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:6796806] R-HSA-5693540.2 summation [Summation:5693892] MRN promotes dissociation of ATM dimers to ATM monomers whic... (hasEvent) [Pathway:2559586] DNA Damage/Telomere Stress Induced Senescence [Homo sapiens] [Pathway:5693548] Sensing of DNA Double Strand Breaks [Homo sapiens] (precedingEvent) [Reaction:349444] Phosphorylation of COP1 at Ser-387 by ATM [Homo sapiens] [Reaction:5686578] Activated ATM phosphorylates ABL1 [Homo sapiens] [Pathway:5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks [Homo sapiens] [Reaction:5693598] ATM phosphorylates NBN [Homo sapiens] [Reaction:5693609] ATM phosphorylates TP53 at S15 [Homo sapiens] [Reaction:6798372] ATM phosphorylates DYRK2 [Homo sapiens] [Reaction:6799097] ATM phosphorylates ZNF420 [Homo sapiens] [Reaction:6800490] ATM phosphorylates PIDD1 [Homo sapiens] [Reaction:6804276] ATM phosphorylates TTC5 [Homo sapiens] [Reaction:6804955] ATM phosphorylates MDM2 [Homo sapiens] (replacementInstances) [_Deleted:6792794] Deletion of instance: 3785786 [_Deleted:6793137] Deletion of instance: 83895 [_Deleted:6793146] Deletion of instance: 75147 (updatedInstance) [_UpdateTracker:9775748] Update Tracker - [Reaction:5693540] MRN activates ATM - v78:[modifyText] [_UpdateTracker:9953667] Update Tracker - [Reaction:5693540] MRN activates ATM - v93:[modifyText]
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