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Details on Person DCLRE1C (ARTEMIS) processes DNA DSB ends

Class:Id	Reaction:5693533
_displayName	DCLRE1C (ARTEMIS) processes DNA DSB ends
_doRelease	TRUE
_timestamp	2015-09-04 20:34:23
authored	[InstanceEdit:73967] Lees-Miller, S, 2003-07-14 15:03:25
catalystActivity	[CatalystActivity:175587] endonuclease activity of p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:DNA DSB ends [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[Complex:5687161] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:DNA DSB ends [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:76272] Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. [LiteratureReference:5687198] The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis [LiteratureReference:5687212] DNA-PK autophosphorylation facilitates Artemis endonuclease activity [LiteratureReference:5687216] DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs [LiteratureReference:5687197] Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining
modified	[InstanceEdit:5693622] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6784748] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DCLRE1C (ARTEMIS) processes DNA DSB ends
output	[Complex:5693546] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:Trimmed DNA DSB ends [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5687183] PRKDC phosphorylates DCLRE1C at DNA DSBs [Homo sapiens] [Reaction:5686924] DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs [Homo sapiens]
releaseDate	2003-11-03
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796804] R-HSA-5693533.2
summation	[Summation:5693555] DCLRE1C (ARTEMIS) possesses an intrinsic 5' to 3' exonucleas...
(hasEvent)	[Pathway:5693571] Nonhomologous End-Joining (NHEJ) [Homo sapiens]
(precedingEvent)	[Reaction:5693578] TDP1 and TDP2 process unligatable DSB ends [Homo sapiens]
(replacementInstances)	[_Deleted:6793166] Deletion of instance: 175585 [_Deleted:6793404] Deletion of instance: 75924
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No pathways have been reviewed or authored by DCLRE1C (ARTEMIS) processes DNA DSB ends (5693533)