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Details on Person The ketimine reductase mu-crystallin protein (CRYM) is a key...

Class:IdSummation:5693340
_displayNameThe ketimine reductase mu-crystallin protein (CRYM) is a key...
_timestamp2015-06-25 15:50:14
created[InstanceEdit:5693366] Jassal, Bijay, 2015-05-15
modified[InstanceEdit:6785231] Jassal, Bijay, 2015-06-25
textThe ketimine reductase mu-crystallin protein (CRYM) is a key enzyme in the pipecolate pathway, which is the main lysine degradation pathway in the brain. One substrate from the pipecolate pathway that can be reduced by CRYM is piperideine-2-carboxylate (P2C) to L-pipecolic acid (PPCA) (Hallen et al 2015). CRYM is also a thyroid hormone binding protein, able to bind and transport 3,5,3'-triiodo-L-thyronine (T3) into nuclei and regulate thyroid hormone-related gene expression (Cheng et al. 2007).
(summation)[Reaction:5693347] CRYM reduces P2C to PPCA [Homo sapiens]
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