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Details on Person PPM1K dephosphorylates p-BCKDH

Class:IdReaction:5693153
_displayNamePPM1K dephosphorylates p-BCKDH
_doReleaseTRUE
_timestamp2024-11-08 15:09:51
authored[InstanceEdit:5693146] Jassal, Bijay, 2015-05-14
catalystActivity[CatalystActivity:5693125] [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity of PPM1K:Mn2+ [mitochondrial matrix]
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:5693146] Jassal, Bijay, 2015-05-14
crossReference[DatabaseIdentifier:9917122] RHEA:77248
edited[InstanceEdit:5693146] Jassal, Bijay, 2015-05-14
goBiologicalProcess[GO_BiologicalProcess:24670] positive regulation of amino acid metabolic process
input[Complex:5693120] p-BCKDH [mitochondrial matrix] [Homo sapiens]
[SimpleEntity:113521] H2O [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
internalReviewed[InstanceEdit:9926227] D'Eustachio, Peter, 2024-10-31
isChimericFALSE
literatureReference[LiteratureReference:5693140] Structural and biochemical characterization of human mitochondrial branched-chain α-ketoacid dehydrogenase phosphatase
modified[InstanceEdit:6785238] Jassal, Bijay, 2015-06-26
[InstanceEdit:6785240] Jassal, Bijay, 2015-06-26
[InstanceEdit:6792911] Jassal, Bijay, 2015-08-28
[InstanceEdit:9672777] D'Eustachio, Peter, 2020-01-02
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9908873] Stephan, Ralf, 2024-04-23
[InstanceEdit:9917131] Stephan, Ralf, 2024-07-30
[InstanceEdit:9925948] D'Eustachio, Peter, 2024-10-28
[InstanceEdit:9926226] D'Eustachio, Peter, 2024-10-31
[InstanceEdit:9927581] Matthews, Lisa, 2024-11-08
[InstanceEdit:9927582] Matthews, Lisa, 2024-11-08
[InstanceEdit:9927658] D'Eustachio, Peter, 2024-11-08
namePPM1K dephosphorylates p-BCKDH
H2O + O-phospho-L-seryl-(3-methyl-2-oxobutanoate dehydrogenase) => L-seryl-(3-methyl-2-oxobutanoate dehydrogenase) + phosphate
negativePrecedingEvent[NegativePrecedingEvent:9908867] Futile Cycle: BCKDK phosphorylates BCKDH
output[Complex:70019] BCKDH [mitochondrial matrix] [Homo sapiens]
[SimpleEntity:113548] Pi [mitochondrial matrix]
[SimpleEntity:113548] Pi [mitochondrial matrix]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2015-09-22
releaseStatusNEW
reviewed[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26
[InstanceEdit:9927657] D'Eustachio, Peter, 2024-11-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6796797] R-HSA-5693153.6
structureModified[InstanceEdit:9925948] D'Eustachio, Peter, 2024-10-28
summation[Summation:5693138] The branched-chain alpha-ketoacid dehydrogenase (BCKDH) comp...
(hasEvent)[Pathway:70895] Branched-chain amino acid catabolism [Homo sapiens]
(normalReaction)[FailedReaction:9912527] H139Hfs13* PPM1K does not dephosphorylate BCKDH [Homo sapiens]
(precedingEvent)[Reaction:9859148] BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV [Homo sapiens]
[Reaction:9859163] DBT transfers BCAA to CoA [Homo sapiens]
[Reaction:9859172] DLD dimer dehydrogenates dihydrolipoyl [Homo sapiens]
[NegativePrecedingEvent:9908874] Futile Cycle: PPM1K dephosphorylates p-BCKDH
(updatedInstance)[_UpdateTracker:9919514] Update Tracker - [Reaction:5693153] PPM1K dephosphorylates p-BCKDH - v90:[modifyText]
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No pathways have been reviewed or authored by PPM1K dephosphorylates p-BCKDH (5693153)
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