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Details on Person FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)

Class:Id	BlackBoxEvent:5693081
_displayName	FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)
_doRelease	TRUE
_timestamp	2015-11-18 11:47:46
authored	[InstanceEdit:5693091] Jassal, Bijay, 2015-05-13
catalystActivity	[CatalystActivity:5693097] endopeptidase activity of FURIN [Golgi membrane]
compartment	[Compartment:622433] Golgi-associated vesicle lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:5693091] Jassal, Bijay, 2015-05-13
edited	[InstanceEdit:5693091] Jassal, Bijay, 2015-05-13
input	[EntityWithAccessionedSequence:5693095] 7K-BACE1 [Golgi-associated vesicle lumen] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5693096] A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase
modified	[InstanceEdit:6783329] Jassal, Bijay, 2015-06-12 [InstanceEdit:6785140] Jassal, Bijay, 2015-06-25 [InstanceEdit:6785240] Jassal, Bijay, 2015-06-26 [InstanceEdit:6792918] Jassal, Bijay, 2015-08-28 [InstanceEdit:6793492] Jassal, Bijay, 2015-09-01 [InstanceEdit:6810581] Jupe, Steve, 2015-11-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)
output	[EntityWithAccessionedSequence:5693106] 7K-BACE1(46-501) [Golgi-associated vesicle lumen] [Homo sapiens] [EntityWithAccessionedSequence:5693069] BACE1(22-45) [Golgi-associated vesicle lumen] [Homo sapiens]
precedingEvent	[BlackBoxEvent:5693071] BACE1 translocates from ER lumen to Golgi apparatus [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26 [InstanceEdit:6809157] Perry, George, 2015-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6797032] R-HSA-5693081.3
summation	[Summation:5693079] FURIN is the most likely endopeptidase that cleaves the BACE...
(hasEvent)	[Pathway:977225] Amyloid fiber formation [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5693092] Unknown deacetylase deacetylates 7K-BACE1(46-501) [Homo sapiens]
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No pathways have been reviewed or authored by FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501) (5693081)