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| Class:Id | Summation:5692943 |
|---|---|
| _displayName | Beta-secretase 1 (BACE1, memapsin-2) mediates the proteolyti... |
| _timestamp | 2015-05-13 16:04:02 |
| created | [InstanceEdit:5692931] Jassal, Bijay, 2015-05-13 |
| modified | [InstanceEdit:5693091] Jassal, Bijay, 2015-05-13 |
| text | Beta-secretase 1 (BACE1, memapsin-2) mediates the proteolytic processing of amyloid precursor protein (APP). BACE1 is transported from the plasma membrane to endosomes where APP hydrolysis takes place. The acid-cluster-dileucine (ACDL) motif in the cytosolic domain of BACE1 is able to bind to the VHS domain of ADP-ribosylation factor-binding proteins 1, 2 and 3 (GGA1,2,3) which play a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. This is the presumed recognition step for BACE1 transport to endosomes (He et al. 2003). |
| (summation) | [Reaction:5692934] BACE1 binds GGA1,2,3 [Homo sapiens] |
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