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Details on Person UniProt:Q99665 IL12RB2
| Class:Id | ReferenceGeneProduct:56920 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Sat February 7 2015;chain:24-862 added on Sat February 7 2015 |
| _displayName | UniProt:Q99665 IL12RB2 |
| _timestamp | 2025-02-21 19:48:46 |
| chain | signal peptide:1-23 chain:24-862 |
| checksum | 67C0E0D946B8DD58 |
| comment | FUNCTION Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.SUBUNIT Heterodimer/heterooligomer; disulfide-linked. The functional high affinity IL12 receptor is composed of I12RB1 and IL12RB2. Il12RB2 binds JAK2 (via its N-terminal) through a membrane-proximal region of the cytoplasmic domain. Interaction, in vitro and in vivo, with SOCS3 (via its SH2 domain) inhibits the STAT4-mediated activation. Binds STAT4 through a membrane-distal C-terminal region.SUBCELLULAR LOCATION Isoform 2 is expressed at similar levels in both naive and activated T-cells.DEVELOPMENTAL STAGE Maximum levels in Th1 cells between day 3 and day 8 of activation.INDUCTION In vitro, up-regulated by IFN-alpha.DOMAIN The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.DOMAIN The box 1 motif is required for JAK interaction and/or activation.PTM On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.POLYMORPHISM Heterozygotic variants Gly-313 and Arg-720 are associated with atopy, an immunological condition that can lead to clinical symptoms such as allergic rhinitis, sinusitis, asthma and eczema.SIMILARITY Belongs to the type I cytokine receptor family. Type 2 subfamily. |
| description | recommendedName: Interleukin-12 receptor subunit beta-2 shortName: IL-12 receptor subunit beta-2 shortName: IL-12R subunit beta-2 shortName: IL-12R-beta-2 shortName: IL-12RB2 |
| geneName | IL12RB2 |
| identifier | Q99665 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Disulfide bond Glycoprotein Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | IL12RB2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957571] ENSEMBL:ENSG00000081985 IL12RB2 [Homo sapiens] |
| secondaryIdentifier | I12R2_HUMAN B1AN98 B7ZKL9 F5H7L6 Q2M3V3 |
| sequenceLength | 862 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:148615] UniProt:Q99665-2 IL12RB2 [Homo sapiens] [ReferenceIsoform:413160] UniProt:Q99665-1 IL12RB2 [Homo sapiens] [ReferenceIsoform:8976537] UniProt:Q99665-3 IL12RB2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:447249] IL12RB2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8950376] p-Y800-IL12RB2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8958284] IL12RB2 [extracellular region] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8950356] O4'-phospho-L-tyrosine at 800 |
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No pathways have been reviewed or authored by UniProt:Q99665 IL12RB2 (56920)
