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Details on Person UniProt:P29460 IL12B
| Class:Id | ReferenceGeneProduct:56916 |
|---|---|
| _chainChangeLog | signal peptide:1-22 added on Sat February 7 2015;chain:23-328 added on Sat February 7 2015 |
| _displayName | UniProt:P29460 IL12B |
| _timestamp | 2024-11-03 19:56:43 |
| chain | signal peptide:1-22 chain:23-328 |
| checksum | 118FA801B8F5BB2F |
| comment | FUNCTION Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.FUNCTION Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.SUBUNIT Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).INTERACTION Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.SIMILARITY Belongs to the IL-12B family.ONLINE INFORMATION IL12B mutation db |
| description | recommendedName: Interleukin-12 subunit beta shortName: IL-12B alternativeName: Cytotoxic lymphocyte maturation factor 40 kDa subunit shortName: CLMF p40 alternativeName: IL-12 subunit p40 alternativeName: NK cell stimulatory factor chain 2 shortName: NKSF2 |
| geneName | IL12B NKSF2 |
| identifier | P29460 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytokine Direct protein sequencing Disulfide bond Glycoprotein Immunoglobulin domain Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | IL12B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:6784996] ENSEMBL:ENSG00000113302 IL12B [Homo sapiens] |
| secondaryIdentifier | IL12B_HUMAN |
| sequenceLength | 328 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:447181] IL12B [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8950126] IL12B [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:8950359] IL12B [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:8950675] IL12B [late endosome lumen] [Homo sapiens] [EntityWithAccessionedSequence:8950760] IL12B [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P29460 IL12B (56916)
