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Details on Person ASPA deacetylates NAASP to acetate and L-aspartate

Class:Id	Reaction:5691507
_displayName	ASPA deacetylates NAASP to acetate and L-aspartate
_doRelease	TRUE
_timestamp	2024-12-03 20:52:40
authored	[InstanceEdit:5691505] Jassal, Bijay, 2015-05-08
catalystActivity	[CatalystActivity:5691509] aspartoacylase activity of ASPA:Zn2+ dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5691505] Jassal, Bijay, 2015-05-08
crossReference	[DatabaseIdentifier:9925768] RHEA:59409
edited	[InstanceEdit:5691505] Jassal, Bijay, 2015-05-08
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:5693772] NAASP [cytosol]
internalReviewed	[InstanceEdit:9926227] D'Eustachio, Peter, 2024-10-31
isChimeric	FALSE
literatureReference	[LiteratureReference:5691518] Identification of the zinc binding ligands and the catalytic residue in human aspartoacylase, an enzyme involved in Canavan disease [LiteratureReference:5692242] Characterization of human aspartoacylase: the brain enzyme responsible for Canavan disease [LiteratureReference:5692214] Structure of aspartoacylase, the brain enzyme impaired in Canavan disease
modified	[InstanceEdit:5691525] Jassal, Bijay, 2015-05-08 [InstanceEdit:5692240] Jassal, Bijay, 2015-05-11 [InstanceEdit:6785238] Jassal, Bijay, 2015-06-26 [InstanceEdit:6785240] Jassal, Bijay, 2015-06-26 [InstanceEdit:6792911] Jassal, Bijay, 2015-08-28 [InstanceEdit:8954511] Jassal, Bijay, 2017-01-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9925772] D'Eustachio, Peter, 2024-10-24 [InstanceEdit:9926226] D'Eustachio, Peter, 2024-10-31 [InstanceEdit:9927661] D'Eustachio, Peter, 2024-11-08 [InstanceEdit:9930378] D'Eustachio, Peter, 2024-12-03
name	ASPA deacetylates NAASP to acetate and L-aspartate H2O + N-acetyl-L-aspartate => acetate + L-aspartate
output	[SimpleEntity:29448] L-Asp [cytosol] [SimpleEntity:29416] CH3COO- [cytosol]
precedingEvent	[BlackBoxEvent:8954513] NAASP translocates from mitochondrial matrix to cytosol [Homo sapiens] [Reaction:8954468] NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAASP [Homo sapiens] [Reaction:5693783] NAALADases hydrolyse NAAG [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26 [InstanceEdit:9927660] D'Eustachio, Peter, 2024-11-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796780] R-HSA-5691507.5
structureModified	[InstanceEdit:9925772] D'Eustachio, Peter, 2024-10-24
summation	[Summation:5692244] Aspartoacylase (ASPA) is a cytosolic zinc metalloenzyme high...
(hasEvent)	[Pathway:8963693] Aspartate and asparagine metabolism [Homo sapiens]
(precedingEvent)	[Reaction:70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp [Homo sapiens] [Reaction:70599] aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] [Homo sapiens] [Reaction:6787757] PXLP-K333-GADL1 decarboxylates acidic AAs [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9928400] Update Tracker - [Reaction:5691507] ASPA deacetylates NAASP to acetate and L-aspartate - v91:[add_removeInput]
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