Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Protein acetylation, which can occur during or after polypep...
| Class:Id | Summation:5691503 |
|---|---|
| _displayName | Protein acetylation, which can occur during or after polypep... |
| _timestamp | 2015-06-12 14:58:56 |
| created | [InstanceEdit:5691505] Jassal, Bijay, 2015-05-08 |
| modified | [InstanceEdit:6783376] Jassal, Bijay, 2015-06-12 |
| text | Protein acetylation, which can occur during or after polypeptide chain biosynthesis, helps protect the intracellular proteins from proteolysis. Acylamino-acid-releasing enzyme (APEH) is a cytosolic enzyme able to catalyse the preferential hydrolysis of terminal acetylated amino acids from small acetylated peptides. APEH prefers substrates with acetylated methionine, alanine and serine residues. Hydrolysis produces an acetylated amino acid and a N-terminus protein (Jones et al. 1991). APEH expression is reduced in renal cell carcinoma therefore may represent a tumor suppressor gene, whose loss contributes to the development of renal cell carcinoma (Erlandsson et al. 1991). The hydrolysis of an acetylated serine residue (NAc-Ser-protein) is shown here. |
| (summation) | [Reaction:5691512] APEH hydrolyses NAc-Ser-protein [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Protein acetylation, which can occur during or after polypep... (5691503)
