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Details on Person UniProt:Q08334 IL10RB
| Class:Id | ReferenceGeneProduct:56912 |
|---|---|
| _chainChangeLog | signal peptide:1-19 added on Fri February 6 2015;chain:20-325 added on Fri February 6 2015 |
| _displayName | UniProt:Q08334 IL10RB |
| _timestamp | 2024-11-03 20:10:16 |
| chain | signal peptide:1-19 chain:20-325 |
| checksum | E470726619AF54C2 |
| comment | FUNCTION Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.SUBUNIT Heterodimer with IFNLR1.INTERACTION Genetic variations in IL10RB influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424].DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the type II cytokine receptor family. |
| description | recommendedName: Interleukin-10 receptor subunit beta shortName: IL-10 receptor subunit beta shortName: IL-10R subunit beta shortName: IL-10RB alternativeName: Cytokine receptor class-II member 4 alternativeName: Cytokine receptor family 2 member 4 shortName: CRF2-4 alternativeName: Interleukin-10 receptor subunit 2 shortName: IL-10R subunit 2 shortName: IL-10R2 cdAntigenNameCDw210b/cdAntigenName |
| geneName | IL10RB CRFB4 D21S58 D21S66 |
| identifier | Q08334 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Antiviral defense Direct protein sequencing Disulfide bond Glycoprotein Membrane Proteomics identification Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | IL10RB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002396] ENSEMBL:ENSG00000243646 IL10RB [Homo sapiens] |
| secondaryIdentifier | I10R2_HUMAN Q9BUU4 |
| sequenceLength | 325 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:448423] IL10RB [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q08334 IL10RB (56912)
