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Details on Person ERCC1:ERCC4 (ERCC1:XPF) DNA endonuclease complex binds 5' to...
| Class:Id | Summation:5690975 |
|---|---|
| _displayName | ERCC1:ERCC4 (ERCC1:XPF) DNA endonuclease complex binds 5' to... |
| _timestamp | 2015-08-11 17:21:35 |
| created | [InstanceEdit:5690974] Orlic-Milacic, Marija, 2015-05-04 |
| modified | [InstanceEdit:6782144] Orlic-Milacic, Marija, 2015-06-04 [InstanceEdit:6783705] Orlic-Milacic, Marija, 2015-06-16 [InstanceEdit:6790528] Orlic-Milacic, Marija, 2015-08-11 |
| text | ERCC1:ERCC4 (ERCC1:XPF) DNA endonuclease complex binds 5' to the DNA damage at global genome nucleotide excision repair (GG-NER) sites to form the incision complex. Binding of ERCC5 (XPG) to the NER site precedes the recruitment of ERCC1:ERCC4 (Riedl et al. 2003). ERCC1 directly interacts with XPA, and this interaction is necessary for the loading of ERCC1:ERCC4 to the open bubble structure in damaged dsDNA and the progression of GG-NER (Tsodikov et al. 2007, Orelli et al. 2010). |
| (summation) | [Reaction:5690991] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER [Homo sapiens] |
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No pathways have been reviewed or authored by ERCC1:ERCC4 (ERCC1:XPF) DNA endonuclease complex binds 5' to... (5690975)
