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Details on Person BCR activation is highly regulated and coreceptors like CD22...
| Class:Id | Summation:5690932 |
|---|---|
| _displayName | BCR activation is highly regulated and coreceptors like CD22... |
| _timestamp | 2015-08-06 16:24:12 |
| created | [InstanceEdit:5690937] Garapati, Phani Vijay, 2015-04-30 |
| literatureReference | [LiteratureReference:5690924] CD22, a B cell-specific immunoglobulin superfamily member, is a sialic acid-binding lectin [LiteratureReference:5690929] Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition [LiteratureReference:5690926] CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity [LiteratureReference:5690938] Characterization of sialyloligosaccharide binding by recombinant soluble and native cell-associated CD22. Evidence for a minimal structural recognition motif and the potential importance of multisite binding [LiteratureReference:5690927] Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment |
| modified | [InstanceEdit:6790044] D'Eustachio, Peter, 2015-08-06 |
| text | BCR activation is highly regulated and coreceptors like CD22 (SIGLEC2) set a signalling threshold to prevent aberrant immune response and autoimmune disease (Cyster et al. 1997, Han et al. 2005). CD22 is a glycoprotein found on the surface of B cells during restricted stages of development. CD22 is a member of the receptors of the sialic acid-binding Ig-like lectin (Siglec) family which binds specifically to the terminal sequence N-acetylneuraminic acid alpha(2-6) galactose (NeuAc-alpha(2-6)-Gal) present on many B-cell glycoproteins (Powell et al. 1993, Sgroi et al. 1993). CD22 has seven immunoglobulin (Ig)-like extracellular domains and a cytoplasmic tail containing six tyrosines, three of which belong to the inhibitory immunoreceptor tyrosine-based inhibition motifs (ITIMs) sequences. Upon BCR cross-linking CD22 is rapidly tyrosine phosphorylated by the tyrosine kinase Lyn, thereby recruiting and activating tyrosine phosphatase, SHP-1 and inhibiting calcium signalling. |
| (summation) | [Pathway:5690714] CD22 mediated BCR regulation [Homo sapiens] |
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