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Details on Person ACO1:4Fe-4S isomerises CIT to ISCIT

Class:IdReaction:5690911
_displayNameACO1:4Fe-4S isomerises CIT to ISCIT
_doReleaseTRUE
_timestamp2024-02-08 17:33:42
authored[InstanceEdit:5690883] Jassal, Bijay, 2015-04-30
catalystActivity[CatalystActivity:5690874] aconitate hydratase activity of ACO1:4Fe-4S [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:5690883] Jassal, Bijay, 2015-04-30
edited[InstanceEdit:5690883] Jassal, Bijay, 2015-04-30
input[SimpleEntity:76190] CIT [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:5690905] A regulated RNA binding protein also possesses aconitase activity
[LiteratureReference:5690879] The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation
[LiteratureReference:5690889] Crystal structure of human iron regulatory protein 1 as cytosolic aconitase
[LiteratureReference:9854277] Cytosolic aconitase activity sustains adipogenic capacity of adipose tissue connecting iron metabolism and adipogenesis
modified[InstanceEdit:5690947] Jassal, Bijay, 2015-05-01
[InstanceEdit:5691198] Jassal, Bijay, 2015-05-05
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8952298] Jassal, Bijay, 2016-12-14
[InstanceEdit:8954232] D'Eustachio, Peter, 2017-01-05
[InstanceEdit:8954301] Jassal, Bijay, 2017-01-06
[InstanceEdit:8954303] Jassal, Bijay, 2017-01-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9854273] Stephan, Ralf, 2023-11-24
[InstanceEdit:9855359] Stephan, Ralf, 2023-12-02
[InstanceEdit:9855365] Stephan, Ralf, 2023-12-02
[InstanceEdit:9860613] D'Eustachio, Peter, 2024-02-08
nameACO1:4Fe-4S isomerises CIT to ISCIT
output[SimpleEntity:389545] ISCIT [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2017-03-27
reviewed[InstanceEdit:8954302] D'Eustachio, Peter, 2017-01-06
[InstanceEdit:9860612] D'Eustachio, Peter, 2024-02-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8882802] R-HSA-5690911.3
structureModified[InstanceEdit:9855359] Stephan, Ralf, 2023-12-02
[InstanceEdit:9855365] Stephan, Ralf, 2023-12-02
summation[Summation:5690893] Cytoplasmic aconitate hydratase (ACO1, iron regulatory prote...
(hasEvent)[Pathway:389542] NADPH regeneration [Homo sapiens]
(precedingEvent)[Reaction:389540] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ [Homo sapiens]
[Reaction:390347] Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane [Homo sapiens]
(updatedInstance)[_UpdateTracker:9864271] Update Tracker - [Reaction:5690911] ACO1:4Fe-4S isomerises CIT to ISCIT - v88:[addLiteratureReference]
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No pathways have been reviewed or authored by ACO1:4Fe-4S isomerises CIT to ISCIT (5690911)
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