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Details on Person ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs

Class:Id	Reaction:5690886
_displayName	ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs
_doRelease	TRUE
_timestamp	2024-03-04 22:26:56
authored	[InstanceEdit:5690883] Jassal, Bijay, 2015-04-30
catalystActivity	[CatalystActivity:9861284] mRNA regulatory element binding translation repressor activity of ACO1, IREB2 [cytosol]
catalystActivityReference	[CatalystActivityReference:9861288] mRNA regulatory element binding translation repressor activity of ACO1, IREB2 [cytosol] A regulated RNA binding protein also possesses aconitase activity
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5690883] Jassal, Bijay, 2015-04-30
edited	[InstanceEdit:5690883] Jassal, Bijay, 2015-04-30
input	[DefinedSet:5690910] ACO1, IREB2 [cytosol] [Homo sapiens] [DefinedSet:5690884] TFRC, ALAD, FTL, FTH1 mRNAs [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5690905] A regulated RNA binding protein also possesses aconitase activity [LiteratureReference:5690879] The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation [LiteratureReference:5690888] Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation [LiteratureReference:5691195] Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation
modified	[InstanceEdit:5691198] Jassal, Bijay, 2015-05-05 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8954301] Jassal, Bijay, 2017-01-06 [InstanceEdit:8954303] Jassal, Bijay, 2017-01-06 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9855363] Stephan, Ralf, 2023-12-02 [InstanceEdit:9861289] D'Eustachio, Peter, 2024-02-16 [InstanceEdit:9861292] D'Eustachio, Peter, 2024-02-16 [InstanceEdit:9863714] D'Eustachio, Peter, 2024-03-04
name	ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs
output	[Complex:5690882] ACO1, IREB2:TFRC, ALAD, FTL, FTH1 mRNAs [cytosol] [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:5691200] Negative regulation by 'GLRX3 [cytosol]' [NegativeRegulation:9855361] Negative regulation by 'Fe2+ [cytosol]'
releaseDate	2017-03-27
reviewed	[InstanceEdit:8954302] D'Eustachio, Peter, 2017-01-06 [InstanceEdit:9861286] Hill, David P, 2024-02-16 [InstanceEdit:9863715] D'Eustachio, Peter, 2024-03-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8907951] R-HSA-5690886.4
structureModified	[InstanceEdit:9855363] Stephan, Ralf, 2023-12-02 [InstanceEdit:9861289] D'Eustachio, Peter, 2024-02-16
summation	[Summation:5690901] Iron and citrate are essential for the metabolism of most or...
(hasEvent)	[Pathway:917937] Iron uptake and transport [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9864242] Update Tracker - [Reaction:5690886] ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs - v88:[addCatalystActivity, addRegulator]
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No pathways have been reviewed or authored by ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs (5690886)