Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person TNFAIP3-interacting protein (TNIPs), also known as A20-bindi...

Class:IdSummation:5690847
_displayNameTNFAIP3-interacting protein (TNIPs), also known as A20-bindi...
_timestamp2016-05-03 14:31:22
created[InstanceEdit:5690836] Jupe, Steve, 2015-04-30
literatureReference[LiteratureReference:5690838] ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling
[LiteratureReference:8869341] The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN
modified[InstanceEdit:5690860] Jupe, Steve, 2015-04-30
[InstanceEdit:8869343] Jupe, Steve, 2016-05-03
textTNFAIP3-interacting protein (TNIPs), also known as A20-binding inhibitors of NF-kappa-B activation (ABINs), bind TNFAIP3, the ubiquitin-editing nuclear factor-kappaB (NF-kappaB) inhibitor protein A20 (Heyninck et al. 1999). Overexpression of TNIPs inhibits NF-kappaB activation by tumor necrosis factor (TNF). TNIPs have a ubiquitin-binding domain that is essential for their NF-kappaB inhibitory and anti-apoptotic activities. They may function as adaptors between ubiquitinated proteins and other regulatory proteins, or disrupt signaling complexes by competing with other ubiquitin-binding proteins (Verstrepen et al. 2009).
(summation)[Reaction:5690845] TNIPs bind TNFAIP3 (A20) [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by TNFAIP3-interacting protein (TNIPs), also known as A20-bindi... (5690847)
Follow Reactome