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Details on Person BAP1 is the catalytic component of the PR-DUB complex, which...

Class:IdSummation:5690795
_displayNameBAP1 is the catalytic component of the PR-DUB complex, which...
_timestamp2016-04-25 10:17:23
created[InstanceEdit:5690772] Jupe, Steve, 2015-04-30
literatureReference[LiteratureReference:5690823] Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
[LiteratureReference:5690747] Loss of the tumor suppressor BAP1 causes myeloid transformation
[LiteratureReference:5690806] MBD5 and MBD6 interact with the human PR-DUB complex through their methyl-CpG-binding domain
[LiteratureReference:5689638] The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression
modified[InstanceEdit:6782615] Jupe, Steve, 2015-06-08
[InstanceEdit:6783445] Jupe, Steve, 2015-06-15
[InstanceEdit:8868786] Jupe, Steve, 2016-04-25
textBAP1 is the catalytic component of the PR-DUB complex, which deubiquitinates Lysine-120 monoubiquitinated Histone H2A (H2AK119ub1) (Scheuermann et al. 2010). The PR-DUB complex consists of BAP1, ASXL1/2, KDM1B, FOXK1/2, HCFC1 and MBD5/6 (Yu et al. 2010, Dey et al. 2012, Baymaz et al. 2014).
(summation)[Reaction:5690790] Histone H2A is dubiquitinated by the PR-DUB complex [Homo sapiens]
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