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Details on Person SCD desaturates ST-CoA to OLE-CoA

Class:Id	Reaction:5690565
_displayName	SCD desaturates ST-CoA to OLE-CoA
_doRelease	TRUE
_timestamp	2024-03-20 19:03:06
authored	[InstanceEdit:5690559] Jassal, Bijay, 2015-04-29
catalystActivity	[CatalystActivity:5690564] stearoyl-CoA 9-desaturase activity of SCD dimer [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:5690559] Jassal, Bijay, 2015-04-29
crossReference	[DatabaseIdentifier:9865944] RHEA:19722
edited	[InstanceEdit:5690559] Jassal, Bijay, 2015-04-29
input	[SimpleEntity:428139] ST-CoA [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29368] O2 [cytosol] [SimpleEntity:4085415] Fe(2+)Cb5 [cytosol] [SimpleEntity:4085415] Fe(2+)Cb5 [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1660625] Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues [LiteratureReference:5690561] Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites [LiteratureReference:8847578] Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells
modified	[InstanceEdit:5690569] Jassal, Bijay, 2015-04-29 [InstanceEdit:6785240] Jassal, Bijay, 2015-06-26 [InstanceEdit:6792911] Jassal, Bijay, 2015-08-28 [InstanceEdit:8854943] D'Eustachio, Peter, 2016-01-29 [InstanceEdit:8978914] D'Eustachio, Peter, 2017-02-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865937] D'Eustachio, Peter, 2024-03-20
name	SCD desaturates ST-CoA to OLE-CoA 2 Fe(II)-(cytochrome b5) + 2 H(+) + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + 2 Fe(III)-(cytochrome b5) + 2 H2O
output	[SimpleEntity:5690558] OLE-CoA [cytosol] [SimpleEntity:4085425] Fe(3+)Cb5 [cytosol] [SimpleEntity:4085425] Fe(3+)Cb5 [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:548831] TECR,TECRL dehydrogenate TOD-CoA to ST-CoA [Homo sapiens] [Reaction:5676637] PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796770] R-HSA-5690565.5
summation	[Summation:5690555] Acyl-CoA desaturase (SCD), located on the ER membrane, is th...
(hasEvent)	[Pathway:75105] Fatty acyl-CoA biosynthesis [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783508] Update Tracker - [Reaction:5690565] SCD desaturates ST-CoA to OLE-CoA - v56:[addLiteratureReference, modifyText]
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