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Details on Person Acyl-CoA desaturase (SCD), located on the ER membrane, is th...
| Class:Id | Summation:5690555 |
|---|---|
| _displayName | Acyl-CoA desaturase (SCD), located on the ER membrane, is th... |
| _timestamp | 2016-01-29 14:43:31 |
| created | [InstanceEdit:5690559] Jassal, Bijay, 2015-04-29 |
| modified | [InstanceEdit:8854943] D'Eustachio, Peter, 2016-01-29 |
| text | Acyl-CoA desaturase (SCD), located on the ER membrane, is the terminal enzyme of the liver microsomal stearyl-CoA desaturase system and is the rate-limiting enzyme in the cellular synthesis of monounsaturated fatty acids (MUFAs) from saturated fatty acids. SCD utilises O2 and electrons from reduced ferrocytochrome b5 (Fe(2+)Cb5) to catalyse the insertion of a double bond into a range of fatty acyl-CoA substrates. This example shows stearoyl-CoA (ST-CoA) desaturation to oleoyl-CoA (OLE-CoA) (Li et al. 1994, Zhang et al. 1999). Studies of tagged recombinant enzyme overexpressed in transiently transfected cells suggest that the enzyme forms dimers and higher oligomers (Zhang et al. 2005). |
| (summation) | [Reaction:5690565] SCD desaturates ST-CoA to OLE-CoA [Homo sapiens] |
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