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Details on Person Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA

Class:IdReaction:5690043
_displayNameCytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA
_doReleaseTRUE
_timestamp2025-12-30 14:34:58
authored[InstanceEdit:5690061] Jassal, Bijay, 2015-04-27
catalystActivity[CatalystActivity:5690067] fatty acyl-CoA hydrolase activity of Cytosolic ACOTs, THEM4 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:5690061] Jassal, Bijay, 2015-04-27
crossReference[DatabaseIdentifier:9978276] RHEA:68185
[DatabaseIdentifier:9914126] RHEA:67681
edited[InstanceEdit:5690061] Jassal, Bijay, 2015-04-27
goBiologicalProcess[GO_BiologicalProcess:8047] acyl-CoA metabolic process
input[DefinedSet:5690044] MCFA-CoA, LCFA-CoA [cytosol]
[SimpleEntity:29356] H2O [cytosol]
internalReviewed[InstanceEdit:9978289] D'Eustachio, Peter, 2025-12-29
isChimericFALSE
literatureReference[LiteratureReference:5690372] New players on the metabolic stage: How do you like Them Acots?
[LiteratureReference:5690404] The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism
[LiteratureReference:5690397] Functional and structural properties of mammalian acyl-coenzyme A thioesterases
[LiteratureReference:5690417] Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs
[LiteratureReference:5690393] Structural basis for regulation of the human acetyl-CoA thioesterase 12 and interactions with the steroidogenic acute regulatory protein-related lipid transfer (START) domain
[LiteratureReference:5690059] Crystal structure of human thioesterase superfamily member 2
[LiteratureReference:5690063] The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis
[LiteratureReference:5690426] Identification of fatty acid oxidation disorder patients with lowered acyl-CoA thioesterase activity in human skin fibroblasts
[LiteratureReference:5690376] A functional variant in the transcriptional regulatory region of gene LOC344967 cosegregates with disease phenotype in familial nasopharyngeal carcinoma
[LiteratureReference:5690413] BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown adipose tissue: cloning, organization of the human gene and assessment of a potential link to obesity
[LiteratureReference:8873829] PC-TP/StARD2: Of membranes and metabolism
[LiteratureReference:8873818] Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling
[LiteratureReference:8873815] Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization
modified[InstanceEdit:5690381] Jassal, Bijay, 2015-04-28
[InstanceEdit:5690549] Jassal, Bijay, 2015-04-29
[InstanceEdit:5695999] Jassal, Bijay, 2015-05-26
[InstanceEdit:6785240] Jassal, Bijay, 2015-06-26
[InstanceEdit:6792911] Jassal, Bijay, 2015-08-28
[InstanceEdit:8873825] Jassal, Bijay, 2016-05-20
[InstanceEdit:8940139] D'Eustachio, Peter, 2016-09-23
[InstanceEdit:8979079] D'Eustachio, Peter, 2017-02-21
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9978272] D'Eustachio, Peter, 2025-12-29
[InstanceEdit:9978288] D'Eustachio, Peter, 2025-12-29
[InstanceEdit:9978313] D'Eustachio, Peter, 2025-12-30
nameCytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA
a medium-chain fatty acyl-CoA + H2O => a medium-chain fatty acid + CoA + H(+)
a long-chain fatty acyl-CoA + H2O => a long-chain fatty acid + CoA + H(+)
output[DefinedSet:5690064] MCFA, LCFA [cytosol]
[SimpleEntity:76194] CoA-SH [cytosol]
[SimpleEntity:70106] H+ [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
regulatedBy[PositiveRegulation:8873902] Positive regulation by 'PCTP [cytosol]'
releaseDate2015-09-22
releaseStatusNEW
reviewed[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26
[InstanceEdit:9978314] D'Eustachio, Peter, 2025-12-30
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6796765] R-HSA-5690043.7
structureModified[InstanceEdit:9978272] D'Eustachio, Peter, 2025-12-29
summation[Summation:5690058] The maintenance/regulation of cellular levels of free fatty ...
(hasEvent)[Pathway:77289] Mitochondrial Fatty Acid Beta-Oxidation [Homo sapiens]
(updatedInstance)[_UpdateTracker:9782409] Update Tracker - [Reaction:5690043] Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA - v59:[add_removeLiteratureReference]
[_UpdateTracker:9782933] Update Tracker - [Reaction:5690043] Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA - v58:[addLiteratureReference, addRegulator, modifyText]
[_UpdateTracker:9984609] Update Tracker - [Reaction:5690043] Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA - v96:[removeOutput]
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