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Details on Person USP2 deubiquitinates MDM2,MDM4

Class:Id	Reaction:5689972
_displayName	USP2 deubiquitinates MDM2,MDM4
_doRelease	TRUE
_timestamp	2016-05-16 07:33:05
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:5689981] cysteine-type deubiquitinase activity of USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5689971] Jupe, Steve, 2015-04-27
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[SimpleEntity:113518] H2O [nucleoplasm] [Complex:6782767] USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5689979] MdmX is a substrate for the deubiquitinating enzyme USP2a [LiteratureReference:5689982] The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2
modified	[InstanceEdit:5690005] Jupe, Steve, 2015-04-27 [InstanceEdit:5696617] Jupe, Steve, 2015-05-29 [InstanceEdit:6781948] Jupe, Steve, 2015-06-03 [InstanceEdit:6782109] Jupe, Steve, 2015-06-04 [InstanceEdit:6782536] Jupe, Steve, 2015-06-08 [InstanceEdit:6782615] Jupe, Steve, 2015-06-08 [InstanceEdit:6782815] Jupe, Steve, 2015-06-09 [InstanceEdit:6782847] Jupe, Steve, 2015-06-09 [InstanceEdit:6805023] Orlic-Milacic, Marija, 2015-10-16 [InstanceEdit:8856275] Jupe, Steve, 2016-02-09 [InstanceEdit:8856346] Orlic-Milacic, Marija, 2016-02-09 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856588] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8871338] Jupe, Steve, 2016-05-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	USP2 deubiquitinates MDM2,MDM4
output	[Complex:6804936] p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5689946] USP2 [nucleoplasm] [Homo sapiens] [DefinedSet:6782682] PolyUb [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6805022] USP2 binds the heterodimer of MDM2 and MDM4 [Homo sapiens] [Reaction:6804724] MDM2 ubiquitinates phosphorylated MDM4 [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861194] R-HSA-5689972.3
summation	[Summation:5689985] The ubiquitin protease USP2 deubiquitinates MDM2 and MDM4 bu...
(hasEvent)	[Pathway:5689880] Ub-specific processing proteases [Homo sapiens] [Pathway:6804757] Regulation of TP53 Degradation [Homo sapiens]
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