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Details on Person USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN

Class:Id	Reaction:5689950
_displayName	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
_doRelease	TRUE
_timestamp	2016-05-19 16:45:51
authored	[InstanceEdit:5688416] Jupe, Steve, 2015-04-16
catalystActivity	[CatalystActivity:6782631] cysteine-type deubiquitinase activity of USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5689971] Jupe, Steve, 2015-04-27
edited	[InstanceEdit:8869523] Jupe, Steve, 2016-05-05
input	[Complex:6782666] USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] [Homo sapiens] [SimpleEntity:113518] H2O [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:3215288] Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization [LiteratureReference:3215284] A dynamic role of HAUSP in the p53-Mdm2 pathway [LiteratureReference:5689959] Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2 [LiteratureReference:5690191] FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP
modified	[InstanceEdit:5690005] Jupe, Steve, 2015-04-27 [InstanceEdit:5690100] Jupe, Steve, 2015-04-27 [InstanceEdit:6781948] Jupe, Steve, 2015-06-03 [InstanceEdit:6782109] Jupe, Steve, 2015-06-04 [InstanceEdit:6782536] Jupe, Steve, 2015-06-08 [InstanceEdit:6782615] Jupe, Steve, 2015-06-08 [InstanceEdit:6782847] Jupe, Steve, 2015-06-09 [InstanceEdit:8869637] Jupe, Steve, 2016-05-06 [InstanceEdit:8871338] Jupe, Steve, 2016-05-16 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
output	[Complex:6782656] USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] [Homo sapiens] [DefinedSet:6782682] PolyUb [nucleoplasm] [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8871339] Meldal, Birgit, 2016-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873324] R-HSA-5689950.3
summation	[Summation:5689954] USP7 (HAUSP) is able to deubiquitinate many substrates. It i...
(hasEvent)	[Pathway:5689880] Ub-specific processing proteases [Homo sapiens]
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No pathways have been reviewed or authored by USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (5689950)