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Details on Person BRCA1-associated protein 1 (BAP1) is a ubiquitin COOH-termin...
| Class:Id | Summation:5689679 |
|---|---|
| _displayName | BRCA1-associated protein 1 (BAP1) is a ubiquitin COOH-termin... |
| _timestamp | 2016-04-25 10:17:33 |
| created | [InstanceEdit:5689675] Jupe, Steve, 2015-04-24 |
| literatureReference | [LiteratureReference:5689648] BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression [LiteratureReference:5689660] BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity [LiteratureReference:8868789] Tumours associated with BAP1 mutations |
| modified | [InstanceEdit:5689684] Jupe, Steve, 2015-04-24 [InstanceEdit:5690772] Jupe, Steve, 2015-04-30 [InstanceEdit:8868786] Jupe, Steve, 2016-04-25 |
| text | BRCA1-associated protein 1 (BAP1) is a ubiquitin COOH-terminal hydrolase that was initially identified as a protein that binds the RING finger domain of the breast and ovarian tumor suppressor BRCA1. The extreme C-terminal segment of BAP1, which is 38% identical to the C-terminus of UCHL5 (UCH37), is necessary for binding to BRCA1 (Jensen et al. 1998). The N-terminal portion of BAP1 binds BARD1 (Nishikawa et al. 2009). BARD1:BRCA1 constitutes a RING heterodimer E3 ligase. BAP1 binding with BARD1 interferes with BARD1-BRCA association. BAP1 can also deubiquitinate the polyubiquitin chains mediated by BRCA1:BARD1 (Nishikawa et al. 2009). BAP1 is a tumour suppressor that is believed to mediate its effects through chromatin modulation, transcriptional regulation, and possibly via the ubiquitin-proteasome system and the DNA damage response pathway (Murali et al. 2013). |
| (summation) | [Reaction:5689649] BAP1 binds BRCA1:BARD1 [Homo sapiens] |
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No pathways have been reviewed or authored by BRCA1-associated protein 1 (BAP1) is a ubiquitin COOH-termin... (5689679)
