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Details on Person DUBs of the Ub C-terminal Hydrolase (UCH) family are thiol p...

Class:IdSummation:5689591
_displayNameDUBs of the Ub C-terminal Hydrolase (UCH) family are thiol p...
_timestamp2015-04-23 15:26:04
created[InstanceEdit:5689562] Jupe, Steve, 2015-04-23
literatureReference[LiteratureReference:5689593] Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases
[LiteratureReference:5689589] Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1
[LiteratureReference:5689577] Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome
modified[InstanceEdit:5689606] Jupe, Steve, 2015-04-23
textDUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Humans have four UCH DUBs (UCH-L1, UCH-L3, UCH37/UCH-L5, and BAP1) that can be divided into the smaller UCH DUBs (UCH-L1 and UCH-L3), which cleave small leaving groups from the C-terminus of ubiquitin (Larsen et al. 1998), and the larger UCH DUBs (UCH37 and BAP1), which can disassemble poly-Ub chains (Misaghi et al. 2009, Lam et al. 1997).
(summation)[Pathway:5689603] UCH proteinases [Homo sapiens]
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