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Details on Person ATXN3 deubiquitinates polyUb-PARK2

Class:Id	Reaction:5688837
_displayName	ATXN3 deubiquitinates polyUb-PARK2
_doRelease	TRUE
_timestamp	2016-05-19 16:45:43
authored	[InstanceEdit:5688416] Jupe, Steve, 2015-04-16
catalystActivity	[CatalystActivity:5689595] cysteine-type deubiquitinase activity of ATXN3:polyUb-PARK2 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5688810] Jupe, Steve, 2015-04-20
edited	[InstanceEdit:8869523] Jupe, Steve, 2016-05-05
input	[Complex:5689561] ATXN3:polyUb-PARK2 [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5688826] The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains [LiteratureReference:5688811] The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability
modified	[InstanceEdit:5688843] Jupe, Steve, 2015-04-20 [InstanceEdit:5689057] Jupe, Steve, 2015-04-21 [InstanceEdit:5689562] Jupe, Steve, 2015-04-23 [InstanceEdit:5689906] Jupe, Steve, 2015-04-24 [InstanceEdit:6781948] Jupe, Steve, 2015-06-03 [InstanceEdit:6782109] Jupe, Steve, 2015-06-04 [InstanceEdit:6783258] Jupe, Steve, 2015-06-11 [InstanceEdit:6786644] Jupe, Steve, 2015-07-09 [InstanceEdit:8869637] Jupe, Steve, 2016-05-06 [InstanceEdit:8871338] Jupe, Steve, 2016-05-16 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ATXN3 deubiquitinates polyUb-PARK2
output	[Complex:5689586] ATXN3:PARK2 [cytosol] [Homo sapiens] [DefinedSet:5689096] PolyUb [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5689085] ATXN3 binds polyUb-PARK2 [Homo sapiens] [Reaction:5689111] PARK2 autoubiquitinates [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8871339] Meldal, Birgit, 2016-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873300] R-HSA-5688837.3
summation	[Summation:5688760] Ataxin-3 (ATXN3) deubiquitinates the C-terminus of PARK2 (P...
(hasEvent)	[Pathway:5689877] Josephin domain DUBs [Homo sapiens]
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