Query author contributions in Reactome
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Details on Person ATP-binding cassette sub-family A member 3 (ABCA3) plays an ...
| Class:Id | Summation:5688391 |
|---|---|
| _displayName | ATP-binding cassette sub-family A member 3 (ABCA3) plays an ... |
| _timestamp | 2015-04-16 10:23:57 |
| created | [InstanceEdit:5688387] Jassal, Bijay, 2015-04-16 |
| text | ATP-binding cassette sub-family A member 3 (ABCA3) plays an important role in the formation of pulmonary surfactant, probably by transporting phospholipids such as phosphatidylcholine (PC) and phosphatidylglycerol (PG) from the ER membrane to lamellar bodies (LBs). PC and PG are the major phospholipid constituents of pulmonary surfactant. LBs are the surfactant storage organelles of type II epithelial cells from where phospholipids can be secreted together with surfactant proteins (SFTPs) into the alveolar airspace. Defects in ABCA3 can cause pulmonary surfactant metabolism dysfunction type 3 (SMDP3; MIM:610921), resulting in respiratory distress in newborns and interstitial lung disease (ILD) in children (Whitsett et al. 2015). |
| (summation) | [Pathway:5688399] Defective ABCA3 causes SMDP3 [Homo sapiens] |
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No pathways have been reviewed or authored by ATP-binding cassette sub-family A member 3 (ABCA3) plays an ... (5688391)
