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Details on Person PARP1,PARP2 dimers bound to MMEJ sites autoPARylate

Class:Id	Reaction:5687653
_displayName	PARP1,PARP2 dimers bound to MMEJ sites autoPARylate
_doRelease	TRUE
_timestamp	2015-09-04 20:33:35
authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5687652] NAD+ poly-ADP-ribosyltransferase activity of Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5687654] Orlic-Milacic, Marija, 2015-04-08
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[Complex:5687643] Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] [Homo sapiens] [SimpleEntity:427523] NAD+ [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5651718] Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage [LiteratureReference:5649874] DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis [LiteratureReference:5687636] The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies [LiteratureReference:5687510] Homologous-recombination-deficient tumours are dependent on Pol?-mediated repair
modified	[InstanceEdit:5687658] Orlic-Milacic, Marija, 2015-04-08 [InstanceEdit:5687760] Orlic-Milacic, Marija, 2015-04-08 [InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 [InstanceEdit:5693270] Orlic-Milacic, Marija, 2015-05-14 [InstanceEdit:5693502] Orlic-Milacic, Marija, 2015-05-15 [InstanceEdit:5693504] Orlic-Milacic, Marija, 2015-05-15 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PARP1,PARP2 dimers bound to MMEJ sites autoPARylate
output	[Complex:5687515] POLQ homodimer [nucleoplasm] [Homo sapiens] [SimpleEntity:427497] NAM [nucleoplasm] [Complex:5687655] Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] [Homo sapiens] [Complex:5651709] PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5687640] POLQ extends annealed 3'-ssDNA overhangs in MMEJ [Homo sapiens] [Reaction:5687484] PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796756] R-HSA-5687653.2
summation	[Summation:5687656] PARP inihibitors that block catalytic activity of PARP1 (or ...
(hasEvent)	[Pathway:5685939] HDR through MMEJ (alt-NHEJ) [Homo sapiens]
(precedingEvent)	[Reaction:5687664] FEN1 cleaves displaced ssDNA flaps during MMEJ [Homo sapiens]
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