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Details on Person Defective SLC34A2 does not cotransport HPO4(2-), 3Na+ from extracellular region to cytosol

Class:IdFailedReaction:5687585
_displayNameDefective SLC34A2 does not cotransport HPO4(2-), 3Na+ from extracellular region to cytosol
_doReleaseTRUE
_timestamp2020-06-26 14:03:30
authored[InstanceEdit:5687621] Jassal, Bijay, 2015-04-08
catalystActivity[CatalystActivity:9631800] sodium:phosphate symporter activity of SLC34A2 mutants [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created[InstanceEdit:5687621] Jassal, Bijay, 2015-04-08
disease[Disease:5651682] pulmonary alveolar microlithiasis
edited[InstanceEdit:5687621] Jassal, Bijay, 2015-04-08
entityFunctionalStatus[EntityFunctionalStatus:5687598] loss_of_function of SLC34A2 mutants [plasma membrane]
input[SimpleEntity:74113] Na+ [extracellular region]
[SimpleEntity:74113] Na+ [extracellular region]
[SimpleEntity:74113] Na+ [extracellular region]
[SimpleEntity:109277] Pi [extracellular region]
literatureReference[LiteratureReference:427624] Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis
[LiteratureReference:5687582] SLC34A2 Gene mutation of pulmonary alveolar microlithiasis: report of four cases and review of literatures
[LiteratureReference:5687601] Pulmonary alveolar microlithiasis: a case report and review of the literature
modified[InstanceEdit:5688016] Jassal, Bijay, 2015-04-13
[InstanceEdit:6791022] Jassal, Bijay, 2015-08-17
[InstanceEdit:9631717] Wu, G, 2018-12-12
[InstanceEdit:9692890] , 2020-07-03
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDefective SLC34A2 does not cotransport HPO4(2-), 3Na+ from extracellular region to cytosol
normalReaction
releaseDate2015-09-22
releaseStatusNEW
reviewed[InstanceEdit:6791021] D'Eustachio, Peter, 2015-08-17
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6797194] R-HSA-5687585.4
summation[Summation:5687618] The human gene SLC34A2 encodes NaPi-2b which is abundantly e...
(hasEvent)[Pathway:5687583] Defective SLC34A2 causes PALM [Homo sapiens]
(updatedInstance)[_UpdateTracker:9776803] Update Tracker - [FailedReaction:5687585] Defective SLC34A2 does not cotransport HPO4(2-), 3Na+ from extracellular region to cytosol - v74:[add_removeInput]
[_UpdateTracker:9778067] Update Tracker - [FailedReaction:5687585] Defective SLC34A2 does not cotransport HPO4(2-), 3Na+ from extracellular region to cytosol - v68:[addCatalystActivity]
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