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Details on Person PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site

Class:IdReaction:5687484
_displayNamePARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site
_doReleaseTRUE
_timestamp2015-09-04 20:33:33
authored[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:5687505] Orlic-Milacic, Marija, 2015-04-08
edited[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input[Complex:5687460] Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:54745] FEN1 [nucleoplasm] [Homo sapiens]
[Complex:5687515] POLQ homodimer [nucleoplasm] [Homo sapiens]
[Complex:5649884] PARP1,PARP2 dimers [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:5687501] Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase ?
[LiteratureReference:5687510] Homologous-recombination-deficient tumours are dependent on Pol?-mediated repair
[LiteratureReference:5687496] Homology and enzymatic requirements of microhomology-dependent alternative end joining
[LiteratureReference:5687506] Mammalian polymerase ? promotes alternative NHEJ and suppresses recombination
[LiteratureReference:5687512] Modulation of DNA end joining by nuclear proteins
[LiteratureReference:5687636] The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies
[LiteratureReference:5649877] AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate
[LiteratureReference:5649874] DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis
[LiteratureReference:5649870] Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair
modified[InstanceEdit:5687637] Orlic-Milacic, Marija, 2015-04-08
[InstanceEdit:5687639] Orlic-Milacic, Marija, 2015-04-08
[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
[InstanceEdit:5693269] Orlic-Milacic, Marija, 2015-05-14
[InstanceEdit:5693504] Orlic-Milacic, Marija, 2015-05-15
[InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24
[InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site
output[Complex:5687514] Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2015-09-22
releaseStatusNEW
reviewed[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6796754] R-HSA-5687484.2
summation[Summation:5687492] Flap endonuclease FEN1, DNA polymerase theta (POLQ) and PARP...
(hasEvent)[Pathway:5685939] HDR through MMEJ (alt-NHEJ) [Homo sapiens]
(precedingEvent)[Reaction:5687640] POLQ extends annealed 3'-ssDNA overhangs in MMEJ [Homo sapiens]
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No pathways have been reviewed or authored by PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (5687484)