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| Class:Id | Summation:5687475 |
|---|---|
| _displayName | The complex of MRN (MRE11A:RAD50:NBN) and RBBP8 (CtIP) perfo... |
| _timestamp | 2015-04-10 19:22:30 |
| created | [InstanceEdit:5687471] Orlic-Milacic, Marija, 2015-04-08 |
| modified | [InstanceEdit:5687907] Orlic-Milacic, Marija, 2015-04-10 |
| text | The complex of MRN (MRE11A:RAD50:NBN) and RBBP8 (CtIP) performs a limited resection of DNA double strand breaks (DSBs) in the process of microhomology-mediated end joining (MMEJ) (Yun et al. 2009). ATM activation inhibits MMEJ-related resection of DNA DSBs by MRN, possibly through MRN phosphorylation (Rahal et al. 2010). |
| (summation) | [Reaction:5687464] MRN and RBBP8 resect DNA DSBs in MMEJ [Homo sapiens] |
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