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Details on Person MRN and RBBP8 resect DNA DSBs in MMEJ

Class:Id	Reaction:5687464
_displayName	MRN and RBBP8 resect DNA DSBs in MMEJ
_doRelease	TRUE
_timestamp	2015-09-04 20:33:31
authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5687463] DNA endonuclease activity of DNA DSB:MRN:RBBP8 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5687459] Orlic-Milacic, Marija, 2015-04-07
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[Complex:5687468] DNA DSB:MRN:RBBP8 [nucleoplasm] [Homo sapiens] [SimpleEntity:113518] H2O [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5684117] CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle [LiteratureReference:5687474] ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining
modified	[InstanceEdit:5687479] Orlic-Milacic, Marija, 2015-04-08 [InstanceEdit:5687518] Orlic-Milacic, Marija, 2015-04-08 [InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 [InstanceEdit:5693279] Orlic-Milacic, Marija, 2015-05-14 [InstanceEdit:5693504] Orlic-Milacic, Marija, 2015-05-15 [InstanceEdit:6784431] Orlic-Milacic, Marija, 2015-06-19 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MRN and RBBP8 resect DNA DSBs in MMEJ
output	[Complex:5687460] Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] [Homo sapiens] [SimpleEntity:30555] dNTP [nucleoplasm]
precedingEvent	[Reaction:5687465] MRN complex binds RBBP8 [Homo sapiens] [BlackBoxEvent:5685953] SIRT6 deacetylates RBBP8 [Homo sapiens] [Reaction:3785768] MRN complex binds DNA double strand breaks [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796752] R-HSA-5687464.2
summation	[Summation:5687475] The complex of MRN (MRE11A:RAD50:NBN) and RBBP8 (CtIP) perfo...
(hasEvent)	[Pathway:5685939] HDR through MMEJ (alt-NHEJ) [Homo sapiens]
(precedingEvent)	[Reaction:5687484] PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site [Homo sapiens]
(replacementInstances)	[_Deleted:6793174] Deletion of instance: 83897
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No pathways have been reviewed or authored by MRN and RBBP8 resect DNA DSBs in MMEJ (5687464)