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Details on Person MAPK6 is degraded by the 26S proteasome

Class:Id	BlackBoxEvent:5687112
_displayName	MAPK6 is degraded by the 26S proteasome
_doRelease	TRUE
_timestamp	2015-05-25 03:51:00
authored	[InstanceEdit:5687134] Rothfels, Karen, 2015-04-06
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5687111] Rothfels, Karen, 2015-04-06
edited	[InstanceEdit:5692861] Rothfels, Karen, 2015-05-13
input	[EntityWithAccessionedSequence:5687000] ub-MAPK6 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5686833] N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome [LiteratureReference:5686836] Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation
modified	[InstanceEdit:5687365] Rothfels, Karen, 2015-04-07 [InstanceEdit:5687372] Rothfels, Karen, 2015-04-07 [InstanceEdit:5691300] Rothfels, Karen, 2015-05-05 [InstanceEdit:5692812] Rothfels, Karen, 2015-05-12 [InstanceEdit:5692851] Rothfels, Karen, 2015-05-13 [InstanceEdit:5693867] Rothfels, Karen, 2015-05-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MAPK6 is degraded by the 26S proteasome
output	[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5687081] MAPK6 is ubiquitinated at the N-terminal [Homo sapiens]
releaseDate	2015-06-17
releaseStatus	NEW
reviewed	[InstanceEdit:5690232] Moens, Ugo, 2015-04-24 [InstanceEdit:5691290] Seternes, Ole-Morten, 2015-05-05 [InstanceEdit:5692746] Mathien, Simon, 2015-05-12 [InstanceEdit:5692748] Meloche, Sylvain, 2015-05-12 [InstanceEdit:5692747] Soulez, Mathilde, 2015-05-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695865] R-HSA-5687112.2
summation	[Summation:5686874] MAPK6 is a short-lived protein with a half-life of 30 minute...
(hasEvent)	[Pathway:5687128] MAPK6/MAPK4 signaling [Homo sapiens]
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No pathways have been reviewed or authored by MAPK6 is degraded by the 26S proteasome (5687112)