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Details on Person Activated ATM phosphorylates DCLRE1C

Class:Id	Reaction:5686704
_displayName	Activated ATM phosphorylates DCLRE1C
_doRelease	TRUE
_timestamp	2015-09-04 20:33:23
authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5686918] protein serine/threonine kinase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5686723] Orlic-Milacic, Marija, 2015-04-02
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[Complex:5686907] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5686702] Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage [LiteratureReference:5686716] Phosphorylation of Artemis following irradiation-induced DNA damage [LiteratureReference:5686707] A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci
modified	[InstanceEdit:5686903] Orlic-Milacic, Marija, 2015-04-05 [InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 [InstanceEdit:5693210] Orlic-Milacic, Marija, 2015-05-14 [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated ATM phosphorylates DCLRE1C
output	[EntityWithAccessionedSequence:5686708] p-S645-DCLRE1C [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm] [Complex:5686692] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAXIP1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5686900] TP53BP1 recruits DCLRE1C to ATM [Homo sapiens] [Reaction:5686685] RIF1 and PAX1IP bind TP53BP1 at DNA DSBs [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796746] R-HSA-5686704.2
summation	[Summation:5686914] Activated ATM phosphorylates DCLRE1C (ARTEMIS) at serine res...
(hasEvent)	[Pathway:5693571] Nonhomologous End-Joining (NHEJ) [Homo sapiens]
(precedingEvent)	[Reaction:5686924] DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs [Homo sapiens]
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No pathways have been reviewed or authored by Activated ATM phosphorylates DCLRE1C (5686704)