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Details on Person Completion of SSA

Class:Id	BlackBoxEvent:5686663
_displayName	Completion of SSA
_doRelease	TRUE
_timestamp	2026-01-26 15:40:28
authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:9980014] DNA ligase activity of LIG1:ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5686671] Orlic-Milacic, Marija, 2015-04-02
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[Complex:9980008] LIG1:ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9980225] Rothfels, Karen, 2026-01-26
isChimeric	FALSE
literatureReference	[LiteratureReference:5358859] Mechanism underlying replication protein a stimulation of DNA ligase I [LiteratureReference:5686229] The DNA damage response: making it safe to play with knives
modified	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 [InstanceEdit:5693237] Orlic-Milacic, Marija, 2015-05-14 [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9980035] Orlic-Milacic, Marija, 2026-01-24 [InstanceEdit:9980137] Orlic-Milacic, Marija, 2026-01-26 [InstanceEdit:9980138] Orlic-Milacic, Marija, 2026-01-26 [InstanceEdit:9980226] Orlic-Milacic, Marija, 2026-01-26
name	Completion of SSA
output	[OtherEntity:5686649] dsDNA with inter-SSA deletion [nucleoplasm] [Complex:176269] ATR:ATRIP [nucleoplasm] [Homo sapiens] [DefinedSet:5685980] EXO1,DNA2:BLM,WRN [nucleoplasm] [Homo sapiens] [OtherEntity:68454] Flap [nucleoplasm] [OtherEntity:68454] Flap [nucleoplasm] [EntityWithAccessionedSequence:3321979] KAT5 [nucleoplasm] [Homo sapiens] [Complex:176353] RAD17:RFC [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:62637] RAD51 [nucleoplasm] [Homo sapiens] [Complex:176312] RAD9:HUS1:RAD1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5684880] RHNO1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5684878] TOPBP1 [nucleoplasm] [Homo sapiens] [DefinedSet:9707299] p-5S-BRCA1:p-2T-BARD1 [nucleoplasm] [Homo sapiens] [Complex:5682166] p-MRN [nucleoplasm] [Homo sapiens] [Complex:5685169] p-RPA heterotrimer [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5693527] p-S1981,Ac-K3016-ATM [nucleoplasm] [Homo sapiens] [Complex:5684137] p-S327,T847,T859-RBBP8 homotetramer [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5687710] p-S990,Ac-K1249-BRIP1 [nucleoplasm] [Homo sapiens] [Complex:5686589] p-Y104-RAD52 heptamer [nucleoplasm] [Homo sapiens] [Complex:109943] ERCC1:ERCC4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:53787] LIG1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5686657] ERCC1:XPF cleaves flaps generated by SSA [Homo sapiens] [Reaction:9980006] ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821385] four stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6797030] R-HSA-5686663.3
structureModified	[InstanceEdit:9980035] Orlic-Milacic, Marija, 2026-01-24
summation	[Summation:5686650] A DNA ligase, most likely LIG1 (DNA ligase I), ligates singl...
(hasEvent)	[Pathway:5685938] HDR through Single Strand Annealing (SSA) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775650] Update Tracker - [BlackBoxEvent:5686663] Completion of SSA - v78:[modifyText] [_UpdateTracker:9984723] Update Tracker - [BlackBoxEvent:5686663] Completion of SSA - v96:[add_removeInput, modifyText, removeCatalystActivity, removeLiteratureReference, removeOutput]
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No pathways have been reviewed or authored by Completion of SSA (5686663)