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Details on Person ERCC1:XPF cleaves flaps generated by SSA

Class:Id	Reaction:5686657
_displayName	ERCC1:XPF cleaves flaps generated by SSA
_doRelease	TRUE
_timestamp	2026-01-26 15:40:35
authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5686658] DNA endonuclease activity of ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5686671] Orlic-Milacic, Marija, 2015-04-02
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[Complex:9980005] ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9980225] Rothfels, Karen, 2026-01-26
isChimeric	FALSE
literatureReference	[LiteratureReference:5686653] Physical and functional interaction between the XPF/ERCC1 endonuclease and hRad52 [LiteratureReference:5686648] ERCC1-XPF endonuclease facilitates DNA double-strand break repair [LiteratureReference:5686669] The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells
modified	[InstanceEdit:5687736] Orlic-Milacic, Marija, 2015-04-08 [InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 [InstanceEdit:5693245] Orlic-Milacic, Marija, 2015-05-14 [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9707304] Orlic-Milacic, Marija, 2020-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9980035] Orlic-Milacic, Marija, 2026-01-24 [InstanceEdit:9980226] Orlic-Milacic, Marija, 2026-01-26
name	ERCC1:XPF cleaves flaps generated by SSA
output	[Complex:9980007] ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9980006] ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA [Homo sapiens] [Reaction:5686642] RAD52 promotes single strand annealing at resected DNA DSBs [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821385] four stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796744] R-HSA-5686657.4
structureModified	[InstanceEdit:9980035] Orlic-Milacic, Marija, 2026-01-24
summation	[Summation:5686670] The endonuclease complex ERCC1:XPF (ERCC1:ERCC4) is recruite...
(hasEvent)	[Pathway:5685938] HDR through Single Strand Annealing (SSA) [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9766949] Futile Cycle: ERCC1:XPF cleaves flaps generated by SSA [NegativePrecedingEvent:9766952] Futile Cycle: ERCC1:XPF cleaves flaps generated by SSA [NegativePrecedingEvent:9766953] Futile Cycle: ERCC1:XPF cleaves flaps generated by SSA [NegativePrecedingEvent:9766954] Futile Cycle: ERCC1:XPF cleaves flaps generated by SSA [NegativePrecedingEvent:9766955] Futile Cycle: ERCC1:XPF cleaves flaps generated by SSA [NegativePrecedingEvent:9766956] Futile Cycle: ERCC1:XPF cleaves flaps generated by SSA [NegativePrecedingEvent:9766958] Futile Cycle: ERCC1:XPF cleaves flaps generated by SSA [NegativePrecedingEvent:9766960] Futile Cycle: ERCC1:XPF cleaves flaps generated by SSA [BlackBoxEvent:5686663] Completion of SSA [Homo sapiens] [BlackBoxEvent:9980021] LIG1 binds SSA sites [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775630] Update Tracker - [Reaction:5686657] ERCC1:XPF cleaves flaps generated by SSA - v78:[modifyText] [_UpdateTracker:9776584] Update Tracker - [Reaction:5686657] ERCC1:XPF cleaves flaps generated by SSA - v75:[add_removeOutput] [_UpdateTracker:9984572] Update Tracker - [Reaction:5686657] ERCC1:XPF cleaves flaps generated by SSA - v96:[add_removeInput, add_removeOutput]
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No pathways have been reviewed or authored by ERCC1:XPF cleaves flaps generated by SSA (5686657)