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Details on Person RAD52 promotes single strand annealing at resected DNA DSBs

Class:Id	Reaction:5686642
_displayName	RAD52 promotes single strand annealing at resected DNA DSBs
_doRelease	TRUE
_timestamp	2015-09-04 20:33:20
authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5686641] annealing activity of RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5686644] Orlic-Milacic, Marija, 2015-04-02
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[Complex:5693590] RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:913267] Visualization of recombination intermediates produced by RAD52-mediated single-strand annealing [LiteratureReference:5686569] Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks [LiteratureReference:83611] Precise binding of single-stranded DNA termini by human RAD52 protein. [LiteratureReference:109575] Structure of the single-strand annealing domain of human RAD52 protein. [LiteratureReference:5686553] Genetic steps of mammalian homologous repair with distinct mutagenic consequences
modified	[InstanceEdit:5686646] Orlic-Milacic, Marija, 2015-04-02 [InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 [InstanceEdit:5693279] Orlic-Milacic, Marija, 2015-05-14 [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6784817] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAD52 promotes single strand annealing at resected DNA DSBs
output	[Complex:5686613] RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5693564] Association of RAD51 with RAD52:DNA double-strand break ends [Homo sapiens] [Reaction:5693580] Association of RAD52 with the RPA complex at resected DNA DSBs [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796743] R-HSA-5686642.2
summation	[Summation:5686643] RAD52 promotes annealing of 3' ssDNA overhangs at resected D...
(hasEvent)	[Pathway:5685938] HDR through Single Strand Annealing (SSA) [Homo sapiens]
(precedingEvent)	[Reaction:9980006] ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775836] Update Tracker - [Reaction:5686642] RAD52 promotes single strand annealing at resected DNA DSBs - v78:[modifyText]
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No pathways have been reviewed or authored by RAD52 promotes single strand annealing at resected DNA DSBs (5686642)