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Details on Person Surfactant catabolism by alveolar macrophages plays a small ...
| Class:Id | Summation:5686366 |
|---|---|
| _displayName | Surfactant catabolism by alveolar macrophages plays a small ... |
| _timestamp | 2015-04-20 12:30:14 |
| created | [InstanceEdit:5686360] Jassal, Bijay, 2015-04-01 |
| modified | [InstanceEdit:5686377] Jassal, Bijay, 2015-04-01 [InstanceEdit:5688902] Jassal, Bijay, 2015-04-20 |
| text | Surfactant catabolism by alveolar macrophages plays a small but critical part in surfactant recycling and metabolism. Upon ligand binding, granulocyte-macrophage colony-stimulating factor receptor (GM-CSF), a heterodimer of alpha (CSF2RA) and beta (CSF2RB) subunits (Hansen et al. 2008), initiates a signalling process that not only induces proliferation, differentiation and functional activation of hematopoietic cells but can also determine surfactant uptake into alveolar macrophages and its degradation via clathrin-coated vesicles. The exact mechanism of surfactant degradation in macrophages is poorly understood (Jain et al. 2005, Ikegami 2006). GM-CSF-deficiency can result in pulmonary alveolar proteinosis (PAP), a lung disease characterised by surfactant accumulation and lipid-engorged alveolar macrophages (Carey & Trapnell 2010). |
| (summation) | [Reaction:5686335] CSF2RA:CSF2RB binds SFTPs [Homo sapiens] [Reaction:5686359] SFTPs translocate from extracellular region to clathrin-coated vesicle [Homo sapiens] |
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