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Details on Person CSF2RA:CSF2RB binds SFTPs

Class:Id	Reaction:5686335
_displayName	CSF2RA:CSF2RB binds SFTPs
_doRelease	TRUE
_timestamp	2015-09-04 20:33:10
authored	[InstanceEdit:5686308] Jassal, Bijay, 2015-04-01
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:5686360] Jassal, Bijay, 2015-04-01
edited	[InstanceEdit:5686308] Jassal, Bijay, 2015-04-01
input	[Complex:5686355] CSF2RA:CSF2RB [plasma membrane] [Homo sapiens] [DefinedSet:5685647] SFTPAs [extracellular region] [Homo sapiens] [Complex:6792856] SFTPB dimer [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:5683685] SFTPC [extracellular region] [Homo sapiens] [Complex:5686241] SFTPD 12mer [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5686352] The molecular basis of pulmonary alveolar proteinosis [LiteratureReference:5686350] Pathways for clearance of surfactant protein A from the lung [LiteratureReference:5686299] Surfactant catabolism [LiteratureReference:913385] The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation
modified	[InstanceEdit:5686378] Jassal, Bijay, 2015-04-01 [InstanceEdit:6791020] Jassal, Bijay, 2015-08-17 [InstanceEdit:6792857] Jassal, Bijay, 2015-08-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CSF2RA:CSF2RB binds SFTPs
output	[Complex:5686345] CSF2RA:CSF2RB:SFTPs [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:5685649] SFTPAs translocate from ER membrane to extracellular region [Homo sapiens] [BlackBoxEvent:5683879] SFTPA genes produce SFTPA proteins [Homo sapiens] [BlackBoxEvent:5684862] SFTPB,C, PC, PG translocate from lamellar body to extracellular region [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6791021] D'Eustachio, Peter, 2015-08-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796734] R-HSA-5686335.2
summation	[Summation:5686366] Surfactant catabolism by alveolar macrophages plays a small ...
(hasEvent)	[Pathway:5683826] Surfactant metabolism [Homo sapiens]
(normalReaction)	[FailedReaction:5688884] Defective CSF2RB does not bind SFTPs [Homo sapiens] [FailedReaction:5688899] Defective CSF2RA does not bind SFTPs [Homo sapiens]
(precedingEvent)	[Reaction:5686359] SFTPs translocate from extracellular region to clathrin-coated vesicle [Homo sapiens]
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No pathways have been reviewed or authored by CSF2RA:CSF2RB binds SFTPs (5686335)