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Details on Person Diagram of HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Defective homologous recombination repair (HRR) due to BRCA1 loss-of-function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function, Impaired BRCA2 binding to SEM1 (DSS1), Impaired BRCA2 binding to RAD51, Impaired BRCA2 binding to PALB2, and Impaired BRCA2 translocation to the nucleus
| Class:Id | PathwayDiagram:5685945 |
|---|---|
| _displayName | Diagram of HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Defective homologous recombination repair (HRR) due to BRCA1 loss-of-function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function, Impaired BRCA2 binding to SEM1 (DSS1), Impaired BRCA2 binding to RAD51, Impaired BRCA2 binding to PALB2, and Impaired BRCA2 translocation to the nucleus |
| _timestamp | 2026-01-26 01:56:54 |
| created | [InstanceEdit:5685944] Orlic-Milacic, Marija, 2015-03-30 |
| height | 2524 |
| modified | [InstanceEdit:5685947] Orlic-Milacic, Marija, 2015-03-30 [InstanceEdit:5685948] Orlic-Milacic, Marija, 2015-03-30 [InstanceEdit:5685965] Orlic-Milacic, Marija, 2015-03-31 [InstanceEdit:5685966] Orlic-Milacic, Marija, 2015-03-31 [InstanceEdit:5685982] Orlic-Milacic, Marija, 2015-03-31 [InstanceEdit:5685988] Orlic-Milacic, Marija, 2015-03-31 [InstanceEdit:5685991] Orlic-Milacic, Marija, 2015-03-31 [InstanceEdit:5685995] Orlic-Milacic, Marija, 2015-03-31 [InstanceEdit:5686097] Orlic-Milacic, Marija, 2015-03-31 [InstanceEdit:5686113] Orlic-Milacic, Marija, 2015-03-31 [InstanceEdit:5686223] Orlic-Milacic, Marija, 2015-03-31 [InstanceEdit:5686224] Orlic-Milacic, Marija, 2015-04-01 [InstanceEdit:5686225] Orlic-Milacic, Marija, 2015-04-01 [InstanceEdit:5686231] Orlic-Milacic, Marija, 2015-04-01 [InstanceEdit:5686411] Orlic-Milacic, Marija, 2015-04-01 [InstanceEdit:5686455] Orlic-Milacic, Marija, 2015-04-01 [InstanceEdit:5686471] Orlic-Milacic, Marija, 2015-04-01 [InstanceEdit:5686494] Orlic-Milacic, Marija, 2015-04-01 [InstanceEdit:5686505] Orlic-Milacic, Marija, 2015-04-01 [InstanceEdit:5686511] Orlic-Milacic, Marija, 2015-04-02 [InstanceEdit:5686544] Orlic-Milacic, Marija, 2015-04-02 [InstanceEdit:5686545] Orlic-Milacic, Marija, 2015-04-02 [InstanceEdit:5686575] Orlic-Milacic, Marija, 2015-04-02 [InstanceEdit:5686591] Orlic-Milacic, Marija, 2015-04-02 [InstanceEdit:5686645] Orlic-Milacic, Marija, 2015-04-02 [InstanceEdit:5686672] Orlic-Milacic, Marija, 2015-04-02 [InstanceEdit:5687458] Orlic-Milacic, Marija, 2015-04-07 [InstanceEdit:5687469] Orlic-Milacic, Marija, 2015-04-07 [InstanceEdit:5687470] Orlic-Milacic, Marija, 2015-04-08 [InstanceEdit:5687479] Orlic-Milacic, Marija, 2015-04-08 [InstanceEdit:5687700] Orlic-Milacic, Marija, 2015-04-08 [InstanceEdit:5687735] Orlic-Milacic, Marija, 2015-04-08 [InstanceEdit:5687736] Orlic-Milacic, Marija, 2015-04-08 [InstanceEdit:5687737] Orlic-Milacic, Marija, 2015-04-08 [InstanceEdit:5687759] Orlic-Milacic, Marija, 2015-04-08 [InstanceEdit:5693280] Orlic-Milacic, Marija, 2015-05-14 [InstanceEdit:5693281] Orlic-Milacic, Marija, 2015-05-14 [InstanceEdit:5693455] Orlic-Milacic, Marija, 2015-05-15 [InstanceEdit:5693456] Orlic-Milacic, Marija, 2015-05-15 [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:5694670] Orlic-Milacic, Marija, 2015-05-22 [InstanceEdit:5694671] Orlic-Milacic, Marija, 2015-05-22 [InstanceEdit:5694673] Orlic-Milacic, Marija, 2015-05-22 [InstanceEdit:6790453] Orlic-Milacic, Marija, 2015-08-10 [InstanceEdit:6792496] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792498] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6809299] Orlic-Milacic, Marija, 2015-11-10 [InstanceEdit:8855180] Wu, G, 2016-02-02 [InstanceEdit:8933488] Jupe, Steve, 2016-08-05 [InstanceEdit:8934878] Orlic-Milacic, Marija, 2016-08-12 [InstanceEdit:9606827] Orlic-Milacic, Marija, 2018-04-25 [InstanceEdit:9645116] Wu, G, 2019-05-03 [InstanceEdit:9704337] Orlic-Milacic, Marija, 2020-10-07 [InstanceEdit:9704648] Orlic-Milacic, Marija, 2020-10-09 [InstanceEdit:9704949] Orlic-Milacic, Marija, 2020-10-15 [InstanceEdit:9707304] Orlic-Milacic, Marija, 2020-11-12 [InstanceEdit:9709283] Orlic-Milacic, Marija, 2020-12-11 [InstanceEdit:9730724] Orlic-Milacic, Marija, 2021-05-10 [InstanceEdit:9731152] Orlic-Milacic, Marija, 2021-05-13 [InstanceEdit:9750994] Orlic-Milacic, Marija, 2021-08-17 [InstanceEdit:9759546] Orlic-Milacic, Marija, 2021-12-06 [InstanceEdit:9762367] May, Bruce, 2022-01-20 [InstanceEdit:9762397] May, Bruce, 2022-01-21 [InstanceEdit:9762426] May, Bruce, 2022-01-24 [InstanceEdit:9763144] Orlic-Milacic, Marija, 2022-01-31 [InstanceEdit:9763178] Orlic-Milacic, Marija, 2022-01-31 [InstanceEdit:9763187] Orlic-Milacic, Marija, 2022-01-31 [InstanceEdit:9763194] Orlic-Milacic, Marija, 2022-01-31 [InstanceEdit:9763396] Orlic-Milacic, Marija, 2022-02-02 [InstanceEdit:9763404] Orlic-Milacic, Marija, 2022-02-02 [InstanceEdit:9763429] Orlic-Milacic, Marija, 2022-02-02 [InstanceEdit:9763664] Orlic-Milacic, Marija, 2022-02-03 [InstanceEdit:9767733] Orlic-Milacic, Marija, 2022-03-01 [InstanceEdit:9817541] Orlic-Milacic, Marija, 2022-09-23 [InstanceEdit:9851388] Orlic-Milacic, Marija, 2023-10-24 [InstanceEdit:9851713] Orlic-Milacic, Marija, 2023-10-30 [InstanceEdit:9851741] Orlic-Milacic, Marija, 2023-10-30 [InstanceEdit:9853656] Orlic-Milacic, Marija, 2023-11-20 [InstanceEdit:9853702] Orlic-Milacic, Marija, 2023-11-20 [InstanceEdit:9853706] Orlic-Milacic, Marija, 2023-11-20 [InstanceEdit:9853709] Orlic-Milacic, Marija, 2023-11-20 [InstanceEdit:9853713] Orlic-Milacic, Marija, 2023-11-20 [InstanceEdit:9853718] Orlic-Milacic, Marija, 2023-11-20 [InstanceEdit:9853877] Orlic-Milacic, Marija, 2023-11-21 [InstanceEdit:9980035] Orlic-Milacic, Marija, 2026-01-24 [InstanceEdit:9980137] Orlic-Milacic, Marija, 2026-01-26 |
| representedPathway | [Pathway:5693567] HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) [Homo sapiens] [Pathway:9701192] Defective homologous recombination repair (HRR) due to BRCA1 loss of function [Homo sapiens] [Pathway:9704331] Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function [Homo sapiens] [Pathway:9704646] Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function [Homo sapiens] [Pathway:9763198] Impaired BRCA2 binding to SEM1 (DSS1) [Homo sapiens] [Pathway:9709570] Impaired BRCA2 binding to RAD51 [Homo sapiens] [Pathway:9709603] Impaired BRCA2 binding to PALB2 [Homo sapiens] [Pathway:9709275] Impaired BRCA2 translocation to the nucleus [Homo sapiens] |
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</Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="5597" reactomeId="113582" position="701 703" bounds="681 688 41 30" textPosition="685 692" /> <org.gk.render.RenderableComplex id="5598" reactomeId="9763139" position="634 849" bounds="554 830 160 38" textPosition="564 846" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-T3387-BRCA2:SEM1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="5620" reactomeId="9853365" position="1605 1565" bounds="1580 1554 51 23" textPosition="1580 1554"> <Properties> <displayName>FIGNL1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="5621" reactomeId="9853387" position="1586 1518" bounds="1563 1507 46 23" textPosition="1563 1507"> <Properties> <displayName>FIRRM</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="5622" reactomeId="9853380" 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reactomeId="53787" position="540 1806" bounds="523 1795 35 23" textPosition="523 1795"> <Properties> <displayName>LIG1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="5782" reactomeId="9980005" position="640 1585" bounds="413 1553 455 64" textPosition="426 1553" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="5955" reactomeId="9980007" position="647 1745" bounds="417 1714 461 62" textPosition="421 1712" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="6061" reactomeId="9980008" position="637 1934" bounds="489 1883 297 102" textPosition="493 1893" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LIG1:ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1</displayName> </Properties> </org.gk.render.RenderableComplex> </Nodes> <Edges> <org.gk.render.RenderableReaction id="3" reactomeId="5684052" points="764 215, 792 185, 828 183" position="792 185" lineWidth="1.0"> <Inputs> <Input id="4" stoichiometry="4" points="740 245" /> <Input id="5" points="729 210" /> </Inputs> <Outputs> <Output id="7" stoichiometry="4" points="849 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1459 374" /> <Output id="13" points="1485 343, 1460 343" /> <Output id="25" points="1466 137, 1447 138" /> <Output id="21" points="1467 98, 1448 99" /> <Output id="23" points="1477 244, 1450 245" /> <Output id="5580" points="1468 206, 1446 206" /> </Outputs> <Catalysts> <Catalyst id="28" points="1342 97" /> </Catalysts> <Properties> <displayName>RNF4 ubiquitinates MDC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="101" reactomeId="5684081" points="1780 345, 1822 344, 1887 343" position="1822 344" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="102" points="1827 402" /> <Input id="26" points="1640 529" /> <Input id="103" points="1745 283" /> </Inputs> <Outputs> <Output id="104" /> </Outputs> <Properties> <displayName>MRN complex binds CDK2 and RBBP8</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="105" reactomeId="5684096" points="1943 272, 1944 225, 1943 188" position="1944 225" lineWidth="1.0"> <Inputs> <Input id="104" points="1999 318" /> <Input id="106" stoichiometry="8" points="1906 289" /> </Inputs> <Outputs> <Output id="107" points="1995 150" /> <Output id="108" stoichiometry="8" points="1872 147" /> <Output id="103" points="1771 251" /> </Outputs> <Catalysts> <Catalyst id="104" points="2018 318, 1985 225" /> </Catalysts> <Properties> <displayName>CDK2 phosphorylates RBBP8</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="109" reactomeId="5684108" points="2091 582, 2152 584, 2197 584" position="2152 584" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="110" points="2370 149" /> <Input id="5545" points="1678 587" /> </Inputs> <Outputs> <Output id="111" /> </Outputs> <Properties> <displayName>BRCA1 binds phosphorylated RBBP8</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="112" reactomeId="5684140" points="2182 122, 2214 123, 2241 122" position="2214 123" lineWidth="1.0"> <Inputs> <Input id="107" points="2152 122" /> <Input id="113" stoichiometry="4" points="2160 160" /> </Inputs> <Outputs> <Output id="114" stoichiometry="4" points="2260 155" /> <Output id="110" points="2284 122" /> </Outputs> <Catalysts> <Catalyst id="107" points="2129 99, 2212 84" /> </Catalysts> <Properties> <displayName>ATM phosphorylates RBBP8</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="194" reactomeId="5684875" points="1607 757, 1573 757, 1532 757" position="1573 757" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="195" points="1627 798" /> <Input id="5427" points="1661 714" /> </Inputs> <Outputs> <Output id="196" /> </Outputs> <Properties> <displayName>Binding of ATR:ATRIP to RPA at resected DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="215" reactomeId="5685011" points="1005 764, 1006 714" position="1006 714" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="216" points="1095 808" /> <Input id="196" points="1200 760" /> <Input id="217" points="1036 811" /> <Input id="218" points="952 813" /> <Input id="219" points="1173 810" /> </Inputs> <Outputs> <Output id="220" /> </Outputs> <Properties> <displayName>ATR activation at DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="239" reactomeId="5685156" points="1132 575, 1131 538, 1132 503" position="1131 538" lineWidth="1.0"> <Inputs> <Input id="220" points="1054 633" /> <Input id="240" points="1187 626" /> </Inputs> <Outputs> <Output id="241" points="1208 433" /> <Output id="242" points="1056 448" /> </Outputs> <Catalysts> <Catalyst id="220" points="1032 633, 1098 539" /> </Catalysts> <Properties> <displayName>ATR phosphorylates RPA2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="261" reactomeId="5684882" points="722 458, 693 458, 648 457" position="693 458" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="262" points="840 361" /> <Input id="263" points="676 514" /> <Input id="242" points="838 437" /> <Input id="264" points="733 568" /> </Inputs> <Outputs> <Output id="265" /> </Outputs> <Properties> <displayName>CHEK1 is recruited to resected DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="302" reactomeId="5684887" points="495 562, 496 592, 495 623" position="496 592" lineWidth="1.0"> <Inputs> <Input id="265" points="497 505" /> <Input id="303" stoichiometry="2" points="465 545" /> </Inputs> <Outputs> <Output id="263" points="627 552" /> <Output id="264" points="661 595" /> <Output id="305" points="507 663" /> <Output id="242" points="975 448, 797 636" /> <Output id="5271" stoichiometry="2" points="435 626" /> </Outputs> <Catalysts> <Catalyst id="265" points="508 505, 526 590" /> </Catalysts> <Properties> <displayName>Activation of CHEK1 at resected DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="306" reactomeId="5685230" points="446 778, 446 809, 447 843" position="446 809" lineWidth="1.0"> <Inputs> <Input id="307" points="461 761" /> <Input id="308" points="400 761" /> </Inputs> <Outputs> <Output id="309" points="512 888" /> <Output id="310" points="429 874" /> </Outputs> <Catalysts> <Catalyst id="305" points="507 713, 480 807" /> </Catalysts> <Properties> <displayName>CHEK1 phosphorylates RAD51</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="311" reactomeId="5685242" points="619 802, 664 785, 720 769" position="664 785" lineWidth="1.0"> <Inputs> <Input id="5593" points="603 765" /> <Input id="5595" points="565 803" /> </Inputs> <Outputs> <Output id="5597" points="705 721" /> <Output id="5598" points="654 827" /> </Outputs> <Catalysts> <Catalyst id="305" points="564 691, 653 699" /> </Catalysts> <Properties> <displayName>CHEK1 phosphorylates BRCA2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="393" reactomeId="5685318" points="1011 1113, 1050 1113, 1088 1114" position="1050 1113" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="394" points="942 1146" /> <Input id="395" points="934 1087" /> <Input id="396" points="1008 1164" /> <Input id="397" points="930 1114" /> </Inputs> <Outputs> <Output id="398" /> </Outputs> <Properties> <displayName>BCDX2 complex formation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="399" reactomeId="5685341" points="1227 1084, 1267 1084, 1312 1085" position="1267 1084" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="398" points="1171 1102" /> <Input id="336" points="1168 1033" /> </Inputs> <Outputs> <Output id="400" /> </Outputs> <Properties> <displayName>BCDX2 complex stabilizes RAD51 filament</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="401" reactomeId="5685319" points="1073 1194, 1107 1193, 1141 1193" position="1107 1193" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="396" points="1040 1185" /> <Input id="402" points="1037 1212" /> </Inputs> <Outputs> <Output id="403" /> </Outputs> <Properties> <displayName>CX3 complex formation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="422" reactomeId="5685838" points="1337 1264, 1337 1303, 1336 1340" position="1337 1303" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="403" points="1210 1209" /> <Input id="423" points="1519 1243" /> </Inputs> <Outputs> <Output id="424" /> </Outputs> <Properties> <displayName>CX3 complex binds D-loop structures</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="448" reactomeId="5685953" points="2003 469, 1963 469, 1923 466" position="1963 469" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="450" stoichiometry="4" points="2035 506" /> <Input id="449" points="2028 450" /> </Inputs> <Outputs> <Output id="102" points="1859 433" /> <Output id="451" stoichiometry="4" points="1882 521" /> <Output id="452" stoichiometry="4" points="1868 471" /> </Outputs> <Catalysts> <Catalyst id="453" points="1965 432" /> </Catalysts> <Properties> <displayName>SIRT6 deacetylates RBBP8</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="575" reactomeId="5685985" points="2672 707, 2671 746, 2672 787" position="2671 746" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4485" points="2614 698" /> <Input id="576" points="2721 667" /> <Input id="593" points="2674 539" /> </Inputs> <Outputs> <Output id="577" /> </Outputs> <Properties> <displayName>EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="776" reactomeId="5685994" points="2284 831, 2243 831, 2201 831" position="2243 831" lineWidth="1.0"> <Inputs> <Input id="777" points="2311 854" /> <Input id="577" points="2518 824" /> </Inputs> <Outputs> <Output id="153" points="2145 820" /> <Output id="779" points="2183 865" /> </Outputs> <Catalysts> <Catalyst id="577" points="2518 810, 2244 793" /> </Catalysts> <Properties> <displayName>Long-range resection of DNA DSBs by EXO1 or DNA2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1898" reactomeId="5686398" points="2074 1642, 2101 1641, 2127 1640" position="2101 1641" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1899" points="2049 1628" /> <Input id="1900" points="2051 1651" /> </Inputs> <Outputs> <Output id="1901" /> </Outputs> <Properties> <displayName>SPIDR binds BLM:TOP3A:RMI1:RMI2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1920" reactomeId="5686410" points="2152 1523, 2177 1524, 2292 1539" position="2177 1524" lineWidth="1.0"> <Inputs> <Input id="1807" points="2097 1524" /> <Input id="1483" points="2139 1542" /> <Input id="1482" points="2144 1514" /> </Inputs> <Outputs> <Output id="1510" points="2787 1390" /> <Output id="1521" points="2791 1304" /> <Output id="1702" points="2247 1420" /> <Output id="5560" points="2239 1502" /> <Output id="1485" points="2258 1561" /> <Output id="1513" points="2815 1625" /> <Output id="5561" points="2783 1688" /> <Output id="1543" points="2677 1755" /> <Output id="4738" points="2345 1886" /> <Output id="4013" points="2231 1890" /> <Output id="1549" points="2803 1527" /> <Output id="1547" points="2808 1457" /> <Output id="4011" points="2463 1868" /> <Output id="4009" points="2375 1373" /> <Output id="5470" points="2589 1829" /> <Output id="5468" points="2408 1434" /> </Outputs> <Catalysts> <Catalyst id="1901" points="2184 1619" /> </Catalysts> <Activators> <Activator id="5640" points="2137 1411, 2169 1444" /> <Activator id="5672" points="2227 1694, 2251 1692, 2252 1615" /> </Activators> <Properties> <displayName>BLM mediates dissolution of double Holliday junction</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2284" reactomeId="5686430" points="1417 1618, 1441 1618, 1475 1618" position="1441 1618" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2286" points="1393 1639" /> <Input id="2285" stoichiometry="2" points="1391 1604" /> </Inputs> <Outputs> <Output id="5476" /> </Outputs> <Properties> <displayName>MUS81 binds EME1, EME2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2470" reactomeId="5686440" points="1933 1247, 1527 1517, 1436 1515" position="1527 1517" lineWidth="1.0"> <Inputs> <Input id="1182" /> </Inputs> <Outputs> <Output id="2471" /> </Outputs> <Catalysts> <Catalyst id="5476" points="1527 1595" /> </Catalysts> <Properties> <displayName>MUS81:EME1,EME2 cleaves D-loop</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2634" reactomeId="5686469" points="1271 1550, 1232 1892" position="1271 1550" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2471" /> </Inputs> <Outputs> <Output id="2636" points="1756 1876" /> <Output id="2635" points="1737 1931" /> <Output id="5422" points="995 2311" /> <Output id="5428" points="1357 1813" /> <Output id="5567" points="1001 1921" /> <Output id="4343" points="1375 1934" /> <Output id="4341" points="1350 1863" /> <Output id="4329" points="1225 1962" /> <Output id="4331" points="1297 1962" /> <Output id="4349" points="1028 1968" /> <Output id="4347" points="1026 2038" /> <Output id="4335" points="1040 2083" /> <Output id="4339" points="982 1857" /> </Outputs> <Properties> <displayName>Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2910" reactomeId="5686475" points="1548 1684, 1576 1684, 1613 1686" position="1576 1684" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="5476" points="1532 1643" /> <Input id="2911" points="1522 1704" /> </Inputs> <Outputs> <Output id="2912" /> </Outputs> <Properties> <displayName>SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="3078" points="1723 1671, 1763 1656" position="1743 1663" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="2912" /> </Inputs> <Outputs> <Output id="3077" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="3223" reactomeId="5686483" points="2101 1742, 2250 1739" position="2250 1739" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="3076" /> </Inputs> <Outputs> <Output id="1510" points="2808 1395" /> <Output id="2636" points="1842 1862" /> <Output id="1521" points="2809 1304" /> <Output id="2635" points="1844 1915" /> <Output id="5422" points="1055 2311, 1865 2129" /> <Output id="1513" points="2815 1635" /> <Output id="5561" points="2721 1711" /> <Output id="1543" points="2659 1775" /> <Output id="4738" points="2338 1886, 2311 1836" /> <Output id="5470" points="2546 1829" /> <Output id="4011" points="2452 1868" /> <Output id="4013" points="2231 1890" /> <Output id="1547" points="2830 1465" /> <Output id="1549" points="2826 1540" /> </Outputs> <Properties> <displayName>Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3234" reactomeId="75998" points="477 1016, 511 1016, 540 1016" position="511 1016" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3235" stoichiometry="7" /> </Inputs> <Outputs> <Output id="3249" /> </Outputs> <Properties> <displayName>Formation of RAD52 heptameric ring structure complexes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3355" reactomeId="5686587" points="643 1066, 673 1066, 700 1064" position="673 1066" lineWidth="1.0"> <Inputs> <Input id="3249" points="606 1038" /> <Input id="3356" stoichiometry="7" points="612 1090" /> </Inputs> <Outputs> <Output id="3357" stoichiometry="7" points="728 1085" /> <Output id="3358" points="733 1029" /> </Outputs> <Catalysts> <Catalyst id="3359" points="673 983" /> </Catalysts> <Properties> <displayName>ABL1 phosphorylates RAD52</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3712" reactomeId="5686642" points="643 1287, 637 1326, 639 1372" position="637 1326" lineWidth="1.0"> <Inputs> <Input id="5430" /> </Inputs> <Outputs> <Output id="3713" /> </Outputs> <Catalysts> <Catalyst id="5430" points="663 1287, 676 1310" /> </Catalysts> <Properties> <displayName>RAD52 promotes single strand annealing at resected DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3858" reactomeId="5686657" points="641 1620, 643 1673, 645 1711" position="643 1673" lineWidth="1.0"> <Inputs> <Input id="5782" /> </Inputs> <Outputs> <Output id="5955" /> </Outputs> <Catalysts> <Catalyst id="5782" points="603 1620, 565 1651" /> </Catalysts> <Properties> <displayName>ERCC1:XPF cleaves flaps generated by SSA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3934" reactomeId="5686663" points="634 1988, 631 2073, 627 2207" position="631 2073" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="6061" /> </Inputs> <Outputs> <Output id="3861" points="481 1474, 377 1469, 377 2050" /> <Output id="3935" points="609 2321" /> <Output id="5685" points="523 1821, 413 1897" /> <Output id="5422" points="941 2311" /> <Output id="3860" stoichiometry="2" points="445 2304" /> <Output id="308" points="375 761, 357 2062" /> <Output id="4207" points="802 2321" /> <Output id="4203" points="863 2247" /> <Output id="4201" points="983 2146" /> <Output id="4199" points="960 2187" /> <Output id="4197" points="452 2260" /> <Output id="4205" points="773 2379" /> <Output id="5567" points="929 1949" /> <Output id="4195" points="931 2219" /> <Output id="4640" points="506 2210" /> <Output id="4339" points="914 1876" /> <Output id="4335" points="989 2107" /> <Output id="4347" points="981 2063" /> <Output id="4349" points="952 2010" /> </Outputs> <Catalysts> <Catalyst id="6061" points="586 1988, 536 2037" /> </Catalysts> <Properties> <displayName>Completion of SSA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5125" reactomeId="5687758" points="1479 913, 1562 913, 1721 909" position="1562 913" lineWidth="1.0"> <Inputs> <Input id="5126" points="1452 936" /> <Input id="335" points="1333 908" /> </Inputs> <Outputs> <Output id="174" points="1734 883" /> <Output id="5129" points="1746 926" /> </Outputs> <Catalysts> <Catalyst id="5127" points="1560 883" /> </Catalysts> <Properties> <displayName>PPP4C:PPP4R2 dephosphorylates RPA2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5272" reactomeId="5693608" points="2518 576, 2550 577, 2585 576" position="2550 577" lineWidth="1.0"> <Inputs> <Input id="111" points="2488 577" /> <Input id="5273" points="2509 607" /> </Inputs> <Outputs> <Output id="154" points="2604 606" /> <Output id="593" points="2635 539" /> </Outputs> <Catalysts> <Catalyst id="111" points="2446 561, 2551 543" /> </Catalysts> <Properties> <displayName>Initial resection of double-strand break ends</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5289" reactomeId="5693542" points="1787 795, 1788 757, 1730 714" position="1788 757" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="153" points="1840 794" /> <Input id="174" points="1746 855" /> </Inputs> <Outputs> <Output id="5427" /> </Outputs> <Properties> <displayName>Association of RPA complexes with ssDNA at resected DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5290" reactomeId="5693561" points="737 902, 806 898, 887 892, 1014 891" position="887 892" lineWidth="1.0"> <Inputs> <Input id="309" stoichiometry="6" points="583 902" /> <Input id="242" points="979 448, 817 639" /> <Input id="5598" points="670 871" /> </Inputs> <Outputs> <Output id="219" points="1178 838" /> <Output id="335" points="1199 902" /> <Output id="216" points="1100 836" /> <Output id="336" points="1111 975" /> <Output id="195" points="1595 816" /> <Output id="217" points="1038 839" /> <Output id="218" points="953 841" /> </Outputs> <Properties> <displayName>RAD51 binds BRCA2 at resected DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5306" reactomeId="5693620" points="1675 1108, 1675 1150, 1675 1193" position="1675 1150" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="435" points="1840 1098" /> <Input id="434" points="1675 1043" /> <Input id="400" points="1608 1102" /> <Input id="436" points="1860 1012" /> </Inputs> <Outputs> <Output id="423" /> </Outputs> <Properties> <displayName>D-loop formation mediated by PALB2, BRCA2 and RAD51</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5307" reactomeId="5693593" points="1561 1371, 1601 1370, 1634 1371" position="1601 1370" lineWidth="1.0"> <Inputs> <Input id="424" points="1489 1372" /> <Input id="1240" points="1547 1398" /> </Inputs> <Outputs> <Output id="1202" points="1647 1396" /> <Output id="1182" points="1909 1247" /> </Outputs> <Catalysts> <Catalyst id="1183" points="1601 1340" /> </Catalysts> <Properties> <displayName>D-loop extension by DNA polymerases</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5339" reactomeId="5693539" points="1979 1247, 1933 1432, 1933 1493" position="1933 1432" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1182" /> </Inputs> <Outputs> <Output id="1807" /> </Outputs> <Properties> <displayName>Ligation of DNA and formation of Holliday structures following repair synthesis</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5340" reactomeId="5693584" points="1932 1564, 1930 1633, 1910 1721" position="1930 1633" lineWidth="1.0"> <Inputs> <Input id="1807" /> </Inputs> <Outputs> <Output id="3076" /> </Outputs> <Catalysts> <Catalyst id="3077" points="1891 1632" /> </Catalysts> <Properties> <displayName>Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5341" reactomeId="5693589" points="2110 1119, 2237 1122, 2629 1272" position="2237 1122" lineWidth="1.0"> <Inputs> <Input id="1182" points="2038 1168" /> <Input id="5542" points="2073 1078" /> <Input id="5544" points="2033 1111" /> </Inputs> <Outputs> <Output id="1510" points="2805 1366" /> <Output id="1521" points="2764 1276" /> <Output id="5558" points="2584 1229" /> <Output id="1443" points="2332 1304" /> <Output id="1513" points="2838 1616" /> <Output id="5561" points="2816 1688" /> <Output id="1543" points="2706 1755" /> <Output id="4738" points="2355 1886" /> <Output id="1549" points="2848 1512" /> <Output id="1547" points="2840 1437" /> <Output id="4009" points="2437 1331" /> <Output id="4013" points="2236 1890" /> <Output id="4011" points="2471 1868" /> <Output id="5470" points="2610 1829" /> <Output id="5468" points="2461 1386" /> <Output id="5540" points="2662 1224" /> </Outputs> <Catalysts> <Catalyst id="1523" points="2233 1003" /> </Catalysts> <Properties> <displayName>D-loop dissociation and strand annealing</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5345" reactomeId="5693558" points="2243 1328, 2243 1358, 2243 1395" position="2243 1358" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1443" /> </Inputs> <Outputs> <Output id="1702" /> </Outputs> <Properties> <displayName>Gap-filling DNA synthesis in SDSA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5432" reactomeId="5693580" points="833 1054, 835 1156, 779 1157" position="835 1156" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3358" points="781 1029" /> <Input id="242" points="983 448, 838 641" /> </Inputs> <Outputs> <Output id="5433" /> </Outputs> <Properties> <displayName>Association of RAD52 with the RPA complex at resected DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5434" reactomeId="5693564" points="394 1194, 396 1253, 445 1252" position="396 1253" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="5433" points="407 1191" /> <Input id="308" points="376 761" /> </Inputs> <Outputs> <Output id="5430" /> </Outputs> <Properties> <displayName>Association of RAD51 with RAD52:DNA double-strand break ends</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="5472" interactionType="Activate" points="539 115, 539 140" position="539 127" lineWidth="2.0"> <Inputs> <Input id="5471" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="5474" interactionType="Activate" points="541 235, 541 301" position="541 268" lineWidth="2.0"> <Inputs> <Input id="5" /> </Inputs> <Outputs> <Output id="5473" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="5570" reactomeId="9709273" points="295 722, 341 717, 561 739" position="341 717" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="5589" /> </Inputs> <Outputs> <Output id="5593" /> </Outputs> <Properties> <displayName>BRCA2 translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5587" reactomeId="9763137" points="110 733, 149 732, 191 730" position="149 732" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="5571" points="71 701" /> <Input id="5588" points="68 777" /> </Inputs> <Outputs> <Output id="5589" /> </Outputs> <Properties> <displayName>BRCA2 binds SEM1 (DSS1)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5619" reactomeId="9853368" points="1633 1532, 1652 1533, 1691 1529" position="1652 1533" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="5620" points="1614 1551" /> <Input id="5621" points="1612 1524" /> </Inputs> <Outputs> <Output id="5622" /> </Outputs> <Properties> <displayName>FIRRM binds FIGNL1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5639" reactomeId="9853389" points="1867 1406, 1893 1318, 2001 1338" position="1893 1318" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1807" points="1916 1493" /> <Input id="5622" points="1739 1509" /> </Inputs> <Outputs> <Output id="5640" /> </Outputs> <Properties> <displayName>FIGNL1 binds RAD51</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5671" reactomeId="9853376" points="1959 1678, 2006 1707, 2121 1701" position="2006 1707" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1900" points="1991 1668" /> <Input id="5622" points="1713 1548, 1677 1659" /> </Inputs> <Outputs> <Output id="5672" /> </Outputs> <Properties> <displayName>FIGNL1 binds SPIDR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5781" reactomeId="9980006" points="638 1477, 638 1506, 639 1550" position="638 1506" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3713" points="639 1450" /> <Input id="3861" points="577 1477" /> </Inputs> <Outputs> <Output id="5782" /> </Outputs> <Properties> <displayName>ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="6067" reactomeId="9980021" points="641 1808, 640 1836, 638 1880" position="640 1836" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="5685" points="561 1806" /> <Input id="5955" points="644 1779" /> </Inputs> <Outputs> <Output id="6061" /> </Outputs> <Properties> <displayName>LIG1 binds SSA sites</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process> |
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No pathways have been reviewed or authored by Diagram of HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Defective homologous recombination repair (HRR) due to BRCA1 loss-of-function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function, Impaired BRCA2 binding to SEM1 (DSS1), Impaired BRCA2 binding to RAD51, Impaired BRCA2 binding to PALB2, and Impaired BRCA2 translocation to the nucleus (5685945)
