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Details on Person UniProt:P06725 UL83
| Class:Id | ReferenceGeneProduct:5685536 |
|---|---|
| _chainChangeLog | chain:1-561 added on Fri May 8 2015 |
| _displayName | UniProt:P06725 UL83 |
| _timestamp | 2026-02-20 21:52:42 |
| chain | chain:1-561 |
| checksum | 37422EA149E88F30 |
| comment | FUNCTION Counteracts the host antiviral immune response when activated and phosphorylated, by preventing host IRF3 from entering the nucleus (PubMed:15452220). Also inhibits the type I interferon production by inactivating the enzymatic activity of DNA sensor CGAS without affecting STING1 (PubMed:29263269, PubMed:40243337). Participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes (PubMed:20504932).SUBUNIT Interacts with host NCL/nucleolin (PubMed:21053310). Interacts with host IFI16 (PubMed:20504932). Interacts with host CGAS; this interaction inhibits CGAS enzymatic activity (PubMed:29263269, PubMed:40243337).INTERACTION As part of the incoming virion, pp65 is targeted to the nucleus immediately after infection (PubMed:7815485). The newly synthesized pp65 is observed in the nucleus until some time after 48 hours postinfection (PubMed:17715235). Thereafter, pp65 is probably exported and accumulates in the cytoplasm (PubMed:17715235). Also found in dense bodies (PubMed:7815485).PTM Phosphorylation may play a role in the localization of the protein.PTM S-nitrosylated. Nitrosylation decreases the inhibition of host CGAS.SIMILARITY Belongs to the herpesviridae pp65 family. |
| created | [InstanceEdit:5685535] Garapati, Phani Vijay, 2015-03-27 |
| description | recommendedName: 65 kDa phosphoprotein shortName: pp65 alternativeName: 65 kDa matrix phosphoprotein alternativeName: Phosphoprotein UL83 alternativeName: Tegument protein UL83 |
| geneName | UL83 |
| identifier | P06725 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Host cytoplasm Host nucleus Host-virus interaction Inhibition of host innate immune response by virus Inhibition of host IRF3 by virus Inhibition of host RLR pathway by virus Phosphoprotein Reference proteome S-nitrosylation Viral immunoevasion Virion Virion tegument |
| modified | [InstanceEdit:5691543] Weiser, JD [InstanceEdit:9015733] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | UL83 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PP65_HCMVA Q7M6K8 |
| sequenceLength | 561 |
| species | [Species:2671791] Human cytomegalovirus |
| (referenceEntity) | [EntityWithAccessionedSequence:5685583] CMVPP65 [viral tegument] [Human cytomegalovirus] |
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No pathways have been reviewed or authored by UniProt:P06725 UL83 (5685536)
