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Details on Person NCR3 (NKp30) is one of the natural cytotoxicity receptors (N...
| Class:Id | Summation:5685420 |
|---|---|
| _displayName | NCR3 (NKp30) is one of the natural cytotoxicity receptors (N... |
| _timestamp | 2015-08-31 22:00:55 |
| created | [InstanceEdit:5685483] Garapati, Phani Vijay, 2015-03-27 |
| literatureReference | [LiteratureReference:5685383] B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors [LiteratureReference:5685473] The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans |
| modified | [InstanceEdit:5693656] Garapati, Phani Vijay, 2015-05-18 [InstanceEdit:6793281] Garapati, Phani Vijay, 2015-08-31 [InstanceEdit:6793282] Garapati, Phani Vijay, 2015-08-31 |
| text | NCR3 (NKp30) is one of the natural cytotoxicity receptors (NCRs) expressed mainly on the surface of the natural killer (NK) cells. NKp30 is a major receptor targeting virus-infected cells, malignantly transformed cells, and immature dendritic cells. NCR3 (NKp30) recognizes tumor antigens B7H6, a member of the B7 family (Kaifu et al. 2011, Brandt et al. 2009). B7H6 is not expressed normally, and is found on tumor cells, and sensitizes targets to NCR3-dependent cytotoxicity by NK cells. |
| (summation) | [Reaction:5685602] NCR3LG1 binds NCR3 [Homo sapiens] |
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No pathways have been reviewed or authored by NCR3 (NKp30) is one of the natural cytotoxicity receptors (N... (5685420)
