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Details on Person GRB2-1:SOS1 binds p-Y-SHC

Class:Id	Reaction:5685366
_displayName	GRB2-1:SOS1 binds p-Y-SHC
_doRelease	TRUE
_timestamp	2016-11-10 00:55:05
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5685364] Jupe, Steve, 2015-03-27
input	[Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens] [DefinedSet:167016] p-Y-SHC [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:110025] Interactions between Src homology SH2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor.
modified	[InstanceEdit:5686058] Jupe, Steve, 2015-03-31 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GRB2-1:SOS1 binds p-Y-SHC
output	[Complex:5685367] GRB2-1:SOS1:p-Y-SHC [cytosol] [Homo sapiens]
precedingEvent	[Reaction:109813] GRB2-1 binds SOS1 [Homo sapiens] [Reaction:167217] Phospho-Shc dissociates from the TrkA receptor [Homo sapiens] [Reaction:167019] SHC, complexed with TrkA, is tyrosine-phosphorylated [Homo sapiens]
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695803] R-HSA-5685366.3
summation	[Summation:5685363] Tyrosine-phosphorylated SHC1 recruits the SH2 domain of the ...
(hasEvent)	[Pathway:167044] Signalling to RAS [Homo sapiens]
(precedingEvent)	[Reaction:5686071] GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS [Homo sapiens]
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No pathways have been reviewed or authored by GRB2-1:SOS1 binds p-Y-SHC (5685366)