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Details on Person BCDX2 complex stabilizes RAD51 filament

Class:Id	Reaction:5685341
_displayName	BCDX2 complex stabilizes RAD51 filament
_doRelease	TRUE
_timestamp	2022-02-24 17:20:55
authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5685342] Orlic-Milacic, Marija, 2015-03-27
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[Complex:5685317] 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] [Homo sapiens] [Complex:5685316] BCDX2 complex [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5685312] Identification and purification of two distinct complexes containing the five RAD51 paralogs [LiteratureReference:5685308] Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway [LiteratureReference:5685621] The HsRAD51B-HsRAD51C stabilizes the HsRAD51 nucleoprotein filament
modified	[InstanceEdit:5685623] Orlic-Milacic, Marija, 2015-03-27 [InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 [InstanceEdit:5693222] Orlic-Milacic, Marija, 2015-05-14 [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6784817] Orlic-Milacic, Marija, 2015-06-22 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9766947] Orlic-Milacic, Marija, 2022-02-24 [InstanceEdit:9766963] Orlic-Milacic, Marija, 2022-02-24 [InstanceEdit:9766971] Orlic-Milacic, Marija, 2022-02-24 [InstanceEdit:9766981] Orlic-Milacic, Marija, 2022-02-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BCDX2 complex stabilizes RAD51 filament
negativePrecedingEvent	[NegativePrecedingEvent:9766943] Futile Cycle: BLM mediates dissolution of double Holliday junction [NegativePrecedingEvent:9766951] Futile Cycle: D-loop dissociation and strand annealing [NegativePrecedingEvent:9766966] Futile Cycle: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 [NegativePrecedingEvent:9766976] Futile Cycle: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
output	[Complex:5685343] 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5685318] BCDX2 complex formation [Homo sapiens] [Reaction:5693561] RAD51 binds BRCA2 at resected DNA DSBs [Homo sapiens] [Reaction:5685242] CHEK1 phosphorylates BRCA2 [Homo sapiens] [Reaction:5685230] CHEK1 phosphorylates RAD51 [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796726] R-HSA-5685341.3
summation	[Summation:5685619] The BCDX2 complex, composed of RAD51 paralogs RAD51B, RAD51C...
(hasEvent)	[Pathway:5693616] Presynaptic phase of homologous DNA pairing and strand exchange [Homo sapiens]
(precedingEvent)	[Reaction:5693620] D-loop formation mediated by PALB2, BRCA2 and RAD51 [Homo sapiens]
(replacementInstances)	[_Deleted:6793215] Deletion of instance: 446345 [_Deleted:6793530] Deletion of instance: 76000
(updatedInstance)	[_UpdateTracker:9775941] Update Tracker - [Reaction:5685341] BCDX2 complex stabilizes RAD51 filament - v78:[modifyText]
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