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Details on Person CHEK1 (Chk1) is a checkpoint kinase activated during genotox...
| Class:Id | Summation:5685215 |
|---|---|
| _displayName | CHEK1 (Chk1) is a checkpoint kinase activated during genotox... |
| _timestamp | 2021-08-16 21:47:21 |
| created | [InstanceEdit:5685216] Orlic-Milacic, Marija, 2015-03-26 |
| modified | [InstanceEdit:5687904] Orlic-Milacic, Marija, 2015-04-10 [InstanceEdit:9750852] Orlic-Milacic, Marija, 2021-08-16 |
| text | CHEK1 (Chk1) is a checkpoint kinase activated during genotoxic stress. CHEK1 activation at resected DNA double-strand breaks (DSBs) involves ATR-mediated phosphorylation of CHEK1 serine residues S317 and S345 in the presence of claspin (CLSPN), TOPBP1, RAD17:RFC complex, RAD9:HUS1:RAD1 complex, TIMELESS:TIPIN complex, RPA complex and RHNO1 (Liu et al. 2000, Zhao and Piwnica-Worms 2001, Kumagai and Dunphy 2003, Sorensen et al. 2004, Wang et al. 2006, Kemp et al. 2010, Cotta-Ramusino et al. 2011, Liu et al. 2012). Following phosphorylation, CHEK1 dissociates from chromatin and phosphorylates target proteins involved in S/G2 checkpoint activation and/or homologous recombination repair (Smits et al. 2006). CLSPN needs to interact with chromatin only transiently in order to facilitate CHEK1 activation (Lee et al. 2005). |
| (summation) | [Reaction:5684887] Activation of CHEK1 at resected DNA DSBs [Homo sapiens] |
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No pathways have been reviewed or authored by CHEK1 (Chk1) is a checkpoint kinase activated during genotox... (5685215)
