Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Activation of CHEK1 at resected DNA DSBs

Class:IdReaction:5684887
_displayNameActivation of CHEK1 at resected DNA DSBs
_doReleaseTRUE
_timestamp2015-09-04 20:32:48
authored[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity[CatalystActivity:5684888] protein serine/threonine kinase activity of ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:5684886] Orlic-Milacic, Marija, 2015-03-23
edited[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
goBiologicalProcess[GO_BiologicalProcess:7962] DNA replication
input[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[Complex:5684883] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:176273] ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
[LiteratureReference:176337] ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
[LiteratureReference:75006] Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.
[LiteratureReference:176211] Rapid PIKK-Dependent Release of Chk1 from Chromatin Promotes the DNA-Damage Checkpoint Response
[LiteratureReference:176140] Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response
[LiteratureReference:5685010] Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress
[LiteratureReference:5685054] Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress
[LiteratureReference:5685173] Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
[LiteratureReference:5685015] A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling
[LiteratureReference:176194] Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1
modified[InstanceEdit:5685217] Orlic-Milacic, Marija, 2015-03-26
[InstanceEdit:5685218] Orlic-Milacic, Marija, 2015-03-26
[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
[InstanceEdit:5693211] Orlic-Milacic, Marija, 2015-05-14
[InstanceEdit:5693456] Orlic-Milacic, Marija, 2015-05-15
[InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16
[InstanceEdit:6784379] Orlic-Milacic, Marija, 2015-06-19
[InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24
[InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameActivation of CHEK1 at resected DNA DSBs
output[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[Complex:5685162] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:176296] p-T916,S945-CLSPN [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:113838] p-S317,S345-CHEK1 [nucleoplasm] [Homo sapiens]
[Complex:5684985] TIMELESS:TIPIN [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2015-09-22
releaseStatusNEW
reviewed[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6796716] R-HSA-5684887.2
summation[Summation:5685215] CHEK1 (Chk1) is a checkpoint kinase activated during genotox...
(hasEvent)[Pathway:5693607] Processing of DNA double-strand break ends [Homo sapiens]
(precedingEvent)[NegativePrecedingEvent:9766937] Futile Cycle: Activation of CHEK1 at resected DNA DSBs
[NegativePrecedingEvent:9766942] Futile Cycle: Activation of CHEK1 at resected DNA DSBs
[NegativePrecedingEvent:9766946] Futile Cycle: Activation of CHEK1 at resected DNA DSBs
[Reaction:5685230] CHEK1 phosphorylates RAD51 [Homo sapiens]
[Reaction:5685242] CHEK1 phosphorylates BRCA2 [Homo sapiens]
[Reaction:6799246] CHEK1 phosphorylates TP53 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775888] Update Tracker - [Reaction:5684887] Activation of CHEK1 at resected DNA DSBs - v78:[modifyText]
[Change default viewing format]
No pathways have been reviewed or authored by Activation of CHEK1 at resected DNA DSBs (5684887)
Follow Reactome