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Details on Person MAP3K8 is phosphorylated

Class:Id	Reaction:5684261
_displayName	MAP3K8 is phosphorylated
_doRelease	TRUE
_timestamp	2024-02-26 21:36:13
authored	[InstanceEdit:5692834] Shamovsky, Veronica, 2015-05-12
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5684256] Shamovsky, Veronica, 2015-03-20
edited	[InstanceEdit:6792550] Shamovsky, Veronica, 2015-08-25
input	[SimpleEntity:113592] ATP [cytosol] [Complex:451638] NFKB1:MAP3K8:TNIP2 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5684245] Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62 [LiteratureReference:5687829] Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals
modified	[InstanceEdit:5687830] Shamovsky, Veronica, 2015-04-10 [InstanceEdit:5692832] Shamovsky, Veronica, 2015-05-12 [InstanceEdit:5692835] Shamovsky, Veronica, 2015-05-12 [InstanceEdit:5693514] Shamovsky, Veronica, 2015-05-15 [InstanceEdit:6791487] Shamovsky, Veronica, 2015-08-20 [InstanceEdit:6792550] Shamovsky, Veronica, 2015-08-25 [InstanceEdit:6793047] Shamovsky, Veronica, 2015-08-28 [InstanceEdit:9032183] Jupe, Steve, 2017-12-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9863032] Shamovsky, Veronica, 2024-02-26
name	MAP3K8 is phosphorylated TPL2 (MAP3K8) is phosphorylated at T290
output	[SimpleEntity:29370] ADP [cytosol] [Complex:5684265] NFKB1:p-T290-MAP3K8:TNIP2 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:168184] Activated TAK1 mediates phosphorylation of the IKK Complex [Homo sapiens] [Reaction:847070] Phosphorylated TAK1 dissociates from the TLR3 receptor complex [Homo sapiens] [BlackBoxEvent:706479] TAK1 is activated [Homo sapiens] [Reaction:936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 [Homo sapiens] [Reaction:936951] Activation of TAK1 complex bound to activated TLR4 complex [Homo sapiens] [Reaction:9645442] Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex [Homo sapiens] [Reaction:5609665] CHUK, IKBKB and IKBKG form IKK complex [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5688083] Jupe, Steve, 2015-04-14 [InstanceEdit:6791477] DeCicco-Skinner, Kathleen L., 2015-08-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796710] R-HSA-5684261.4
summation	[Summation:5684251] The activity of tumor progression locus-2 (TPL2, also known ...
systematicName	IKBKB phosphorylates MAP3K8
(hasEvent)	[Pathway:5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation [Homo sapiens]
(precedingEvent)	[Reaction:5684248] SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9863960] Update Tracker - [Reaction:5684261] MAP3K8 is phosphorylated - v88:[modifyText, removeLiteratureReference]
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