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Details on Person MRN complex binds CDK2 and RBBP8

Class:Id	Reaction:5684081
_displayName	MRN complex binds CDK2 and RBBP8
_doRelease	TRUE
_timestamp	2022-02-24 17:10:23
authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5684101] Orlic-Milacic, Marija, 2015-03-19
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[Complex:187952] CCNA:p-T160-CDK2 [nucleoplasm] [Homo sapiens] [Complex:5684097] RBBP8 homotetramer [nucleoplasm] [Homo sapiens] [Complex:5682162] DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5684082] Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2 [LiteratureReference:5684093] CtIP tetramer assembly is required for DNA-end resection and repair
modified	[InstanceEdit:5685965] Orlic-Milacic, Marija, 2015-03-31 [InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 [InstanceEdit:5693279] Orlic-Milacic, Marija, 2015-05-14 [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:9766963] Orlic-Milacic, Marija, 2022-02-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MRN complex binds CDK2 and RBBP8
negativePrecedingEvent	[NegativePrecedingEvent:9766961] Futile Cycle: CDK2 phosphorylates RBBP8
output	[Complex:5684094] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5684071] RNF4 ubiquitinates MDC1 [Homo sapiens] [Reaction:5684052] PIAS4 SUMOylates MDC1 [Homo sapiens] [BlackBoxEvent:5685953] SIRT6 deacetylates RBBP8 [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796704] R-HSA-5684081.3
summation	[Summation:5684090] In the S/G2 phase of the cell cycle, CDK2:CCNA (CDK2:cyclin ...
(hasEvent)	[Pathway:5693607] Processing of DNA double-strand break ends [Homo sapiens]
(precedingEvent)	[Reaction:5684096] CDK2 phosphorylates RBBP8 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776082] Update Tracker - [Reaction:5684081] MRN complex binds CDK2 and RBBP8 - v78:[modifyText]
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No pathways have been reviewed or authored by MRN complex binds CDK2 and RBBP8 (5684081)