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Details on Person RNF4 ubiquitinates MDC1

Class:Id	Reaction:5684071
_displayName	RNF4 ubiquitinates MDC1
_doRelease	TRUE
_timestamp	2022-01-20 20:48:24
authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5684070] ubiquitin protein ligase activity of RNF4 homodimer [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5684075] Orlic-Milacic, Marija, 2015-03-18
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
input	[Complex:5684053] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:4570503] Sumoylation of MDC1 is important for proper DNA damage response [LiteratureReference:5655625] SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage [LiteratureReference:5684059] RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair
modified	[InstanceEdit:5684106] Orlic-Milacic, Marija, 2015-03-19 [InstanceEdit:5684110] Orlic-Milacic, Marija, 2015-03-19 [InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 [InstanceEdit:5693279] Orlic-Milacic, Marija, 2015-05-14 [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:6792494] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792497] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792618] Orlic-Milacic, Marija, 2015-08-25 [InstanceEdit:6809298] Orlic-Milacic, Marija, 2015-11-10 [InstanceEdit:9707304] Orlic-Milacic, Marija, 2020-11-12 [InstanceEdit:9762366] May, Bruce, 2022-01-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RNF4 ubiquitinates MDC1
output	[Complex:5682162] DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] [Homo sapiens] [Complex:5684077] K48PolyUb:SUMO2:K1840,p-5T-MDC1 dimer [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5683418] p-S25,S1778-TP53BP1 [nucleoplasm] [Homo sapiens] [Complex:5682998] K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4551605] RNF168 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:2993789] PIAS4 [nucleoplasm] [Homo sapiens] [Complex:5682542] UBE2N:UBE2V2 [nucleoplasm] [Homo sapiens] [Complex:5682540] RNF8:Zn2+ [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5682575] p-S406-FAM175A [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5682574] UIMC1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5682579] BRE [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5682577] BRCC3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5682582] BABAM1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5682984] p-S102-WHSC1 [nucleoplasm] [Homo sapiens] [DefinedSet:9707299] p-5S-BRCA1:p-2T-BARD1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5682615] p-T4827,SUMO1-HERC2 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5684052] PIAS4 SUMOylates MDC1 [Homo sapiens] [Reaction:5683801] CHEK2 phosphorylates BRCA1 [Homo sapiens]
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796703] R-HSA-5684071.5
summation	[Summation:5684102] SUMOylation of MDC1 by PIAS4 creates a docking site for RNF4...
(hasEvent)	[Pathway:5693607] Processing of DNA double-strand break ends [Homo sapiens]
(precedingEvent)	[Reaction:5684081] MRN complex binds CDK2 and RBBP8 [Homo sapiens] [Reaction:5684108] BRCA1 binds phosphorylated RBBP8 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775091] Update Tracker - [Reaction:5684071] RNF4 ubiquitinates MDC1 - v80:[add_removeOutput] [_UpdateTracker:9775817] Update Tracker - [Reaction:5684071] RNF4 ubiquitinates MDC1 - v78:[modifyText] [_UpdateTracker:9776531] Update Tracker - [Reaction:5684071] RNF4 ubiquitinates MDC1 - v75:[add_removeOutput] [_UpdateTracker:9783873] Update Tracker - [Reaction:5684071] RNF4 ubiquitinates MDC1 - v55:[add_removeOutput]
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